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GENE:

WNT11 (Wnt Family Member 11)

News alerts, weekly reports and conference planners

Gene expression profiles associated with carboplatin chemoresistance in high-grade serous ovarian cancer: insights from 2D and 3D models. (PubMed, Biomed Pharmacother)

These results identify MMP9, TWIST2, ZEB2, and WNT11 as promising biomarkers for overcoming chemoresistance in HGSOC. Further functional validation of these genes is needed to confirm the biological significance of the observed correlations.

1 month ago

Journal • Gene Expression Profile

MMP9 (Matrix metallopeptidase 9) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • WNT11 (Wnt Family Member 11)

carboplatin

2ms

Rewiring immune evasion in liver metastases: WNT11 as a central node - a mini review. (PubMed, Front Oncol)

Additionally, circulating WNT11 levels may also serve as a predictive biomarker for patient stratification and treatment monitoring. Despite challenges related to pathway complexity and tumor heterogeneity, this mini review synthesizes recent advances in understanding the WNT11-driven tumor-immune axis and proposes a translational roadmap for combination strategies to overcome ICB resistance in liver metastasis.

2 months ago

Review • Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • IDO1 (Indoleamine 2,3-dioxygenase 1) • TGFB1 (Transforming Growth Factor Beta 1) • WNT11 (Wnt Family Member 11)

3ms

Gene Expression Profiling Provides an Improved Characterization of CD79B-Mutated Diffuse Large B-Cell Lymphomas. (PubMed, J Pers Med)

TP53 mutation showed an association with poorer overall survival in a secondary analysis, consistent with prior reports, while survival by CD79B/MYD88 mutation status and the differentially expressed genes showed no significant differences in this cohort. In conclusion, the current study identified novel up-regulated genes in CD79B-mutated DLBCLs beyond NF-κB pathway signaling, which may contribute to a better definition of potential therapeutic targets and further improves the characterization of this distinct and aggressive DLBCL subgroup.

3 months ago

Journal

TP53 (Tumor protein P53) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • RUNX1 (RUNX Family Transcription Factor 1) • CD79B (CD79b Molecule) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CARD11 (Caspase Recruitment Domain Family Member 11) • IL10 (Interleukin 10) • CD14 (CD14 Molecule) • PIM1 (Pim-1 Proto-Oncogene) • BCL2A1 (BCL2 Related Protein A1) • GZMB (Granzyme B) • IL7 (Interleukin 7) • RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) • AFDN (Afadin, Adherens Junction Formation Factor) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • WNT11 (Wnt Family Member 11)

TP53 mutation

5ms

Comprehensive bioinformatics analysis reveals prognostic significance and immunological roles of WNT gene family in breast cancer. (PubMed, Sci Rep)

Furthermore, co-expression and drug sensitivity analyses revealed that WNTs influence the efficacy of multiple anti-cancer agents, offering potential targets for precision oncology. This study provides novel insights into the multifaceted role of WNT genes in BRCA, identifying them as promising prognostic indicators and immunotherapeutic targets that warrant further clinical exploration.

5 months ago

Journal • BRCA Biomarker • IO biomarker

BRCA (Breast cancer early onset) • WNT11 (Wnt Family Member 11) • WNT7B (Wnt Family Member 7B) • WNT2 (Wnt Family Member 2)

5ms

Polymorphisms and environmental factors associated with orofacial clefts as potential markers for oral cancer risk. (PubMed, Braz Oral Res)

However, place of residence (adjusted OR:5.46, p < 0.001, 95%CI: 3.76-63.543), and three genetic variants-rs1533767 (OR: 1.94, p = 0.042, 95%CI: 1.018-3.694), rs3923087 (OR: 0.58, p = 0.038, 95%CI: 0.344-0.974), rs11867417 (OR: 0.51, p = 0.010, 95%CI: 0.304-0.857)-were associated with oral potentially malignant disorders and oral squamous cell carcinoma. These findings suggest that specific environmental risk factors and genetic variants may be associated with increased susceptibility to oral potentially malignant disorders and oral cancer.

5 months ago

Journal

WNT11 (Wnt Family Member 11)

6ms

Outcomes of primary CNS lymphoma treated with combined immunochemotherapy with whole-brain radiotherapy. (PubMed, Ann Hematol)

Our study demonstrates that contemporary HD-MTX-based chemoimmunotherapy induction regimens achieve good disease responses in PCNSL. We also highlight significant prognostic factors and a potential role for immunotherapy in PCNSL.

6 months ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD44 (CD44 Molecule) • WNT11 (Wnt Family Member 11)

Rituxan (rituximab) • methotrexate • methotrexate IV

6ms

Immune profiling showed distinct microenvironment features in high-risk groups, along with differential sensitivity to specific chemotherapeutic agents (eg, BMS-754807)...The established risk model provides novel molecular markers and potential therapeutic targets for personalized GC treatment. These findings offer critical insights for understanding GC pathogenesis and developing innovative treatment strategies.

6 months ago

Journal • IO biomarker

TGFB1 (Transforming Growth Factor Beta 1) • TGFB2 (Transforming Growth Factor Beta 2) • WNT11 (Wnt Family Member 11)

BMS-754807

7ms

GRK5 as a Novel Therapeutic Target for Immune Evasion in Testicular Cancer: Insights from Multi-Omics Analysis and Immunotherapeutic Validation. (PubMed, Biomedicines)

Complementary immunological validation established that specific targeting of GRK5 with the selective antagonist GRK5-IN-2 disrupts immune evasion pathways in testicular cancer, as quantified by T-cell-mediated cytotoxicity. These findings position GRK5 as a critical modulator of tumor-immune escape, warranting further preclinical exploration of GRK5-IN-2 as a candidate immunotherapeutic agent.

7 months ago

Journal • IO biomarker

FSCN1 (Fascin Actin-Bundling Protein 1) • WNT11 (Wnt Family Member 11)

12ms

Gene expression associated with endocrine therapy resistance in estrogen receptor-positive breast cancer. (PubMed, Sci Rep)

EZH2 and TOP2A were positively correlated with proliferation scores, while WNT11 and ITGB6 emerged as potential biomarkers independently associated with recurrence. These findings suggest novel biomarker candidates that could help overcome ET resistance, reduce recurrence, and improve outcomes in ER + BC.

12 months ago

Journal

ER (Estrogen receptor) • PTEN (Phosphatase and tensin homolog) • TOP2A (DNA topoisomerase 2-alpha) • ITGB6 (Integrin Subunit Beta 6) • MME (Membrane Metalloendopeptidase) • SNAI2 (Snail Family Transcriptional Repressor 2) • WNT11 (Wnt Family Member 11)

ER positive

Prosigna™ Breast Cancer Prognostic Gene Signature Assay

1year

Poly- and per-fluoroalkyl substances toxicity on skeletal and cognitive well-being: a comprehensive review. (PubMed, J Environ Sci Health C Toxicol Carcinog)

Further research is required in several areas, such as age-specific toxicological effects of PFAS, impact of various other PFAS compounds beyond perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and involvement of peroxisome proliferator-activated receptors in PFAS-induced toxicity. Regarding brain toxicity, extensive research in adults is required as there is currently a relative scarcity of studies in this age group when compared to the available research conducted on children and older individuals.

1 year ago

Review • Journal

GSK3B (Glycogen Synthase Kinase 3 Beta) • WNT11 (Wnt Family Member 11)

1year

WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis. (PubMed, Nat Commun)

Serum expression of WNT11 is identified as a potential minimally invasive biomarker in the management of colorectal cancer-LM with immunotherapy. Our findings highlight WNT11/CAMKII axis as a critical regulator of the TME and a promising target for immunotherapy in patients with LM.

1 year ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CCL4 (Chemokine (C-C motif) ligand 4) • AFF3 (AF4/FMR2 Family Member 3) • WNT11 (Wnt Family Member 11)

over1year

Developmental toxicity assay of xanthatin in zebrafish embryos. (PubMed, Comp Biochem Physiol C Toxicol Pharmacol)

Mitophagy related genes pink1 and parkin, and wnt pathway (β-catenin, wnt8a and wnt11) were significantly increased after xanthatin exposure. Taken together, our finding indicated that xanthatin induced developmental toxicity, and the ROS elevation, apoptosis activation, dysregulation of mitophagy and wnt pathways were involved in the toxicity caused by xanthatin.

over 1 year ago

Journal

KEAP1 (Kelch Like ECH Associated Protein 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CASP3 (Caspase 3) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • PINK1 (PTEN Induced Kinase 1) • WNT11 (Wnt Family Member 11)