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    GENE:

    WNK2 (WNK Lysine Deficient Protein Kinase 2)

    i
    Other names: WNK2, WNK Lysine Deficient Protein Kinase 2, Serologically Defined Colon Cancer Antigen 43, NY-CO-43, KIAA1760, SDCCAG43, PRKWNK2, Serine/Threonine-Protein Kinase WNK2, Protein Kinase Lysine-Deficient 2, Protein Kinase With No Lysine 2, Antigen NY-CO-43, Mitogen-Activated Protein Kinase Kinase Kinase, P/OKcl.13
    21d
    WNK2 may promote ovarian cancer progression by upregulating POU5F1B. (PubMed, PLoS One)
    Together, these results demonstrate that WNK2 promotes OC progression by upregulating the validated oncogene POU5F1B and activating AKT signaling. These findings establish WNK2 as an oncogenic driver and a promising therapeutic target in OC.
    Journal
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    WNK2 (WNK Lysine Deficient Protein Kinase 2)
    1year
    Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS). (PubMed, Cancer Med)
    In conclusion, we uncovered new insights into the mutational landscape of WM, depicting a more complex involvement of the NF-kB pathway, and providing evidence of the recurrence of some variants (MYD88, IL17RB, NFKB2, ATM, CARD11, PTPN13, and WNK2) also in IgM MGUS.
    Journal
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    ARID1A (AT-rich interaction domain 1A) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • KMT2D (Lysine Methyltransferase 2D) • CD79B (CD79b Molecule) • KMT2C (Lysine Methyltransferase 2C) • CARD11 (Caspase Recruitment Domain Family Member 11) • SDC1 (Syndecan 1) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • WNK2 (WNK Lysine Deficient Protein Kinase 2) • IL17RB (Interleukin 17 Receptor B)
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    ARID1A mutation • MYD88 mutation • MYD88 L265P
    2years
    Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers. (PubMed, Pathol Res Pract)
    In immunohistochemistry for WNK2, WNK2 expression in the MSI-H CCs was significantly lower than that in the MSS CCs. Our results for the mutation and expression indicate that STARD8 and WNK2 genes are altered at various levels (frameshift mutation, expression, and regional heterogeneity) in MSI-H CCs, which might play a role in the pathogenesis by inactivating their TSG functions.
    Journal • MSi-H Biomarker
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    MSI (Microsatellite instability) • WNK2 (WNK Lysine Deficient Protein Kinase 2)
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    MSI-H/dMMR