WIF1 (WNT Inhibitory Factor 1)

DNA methylation and microRNA biomarkers hold strong promises for non-invasive CRC screening. Multi-marker panels demonstrate superior diagnostic accuracy and may provide a cost-effective, scalable approach for early CRC detection in resource-limited settings.

It has been shown that circ_0006840 was transcriptionally activated by HIF1A and specifically regulated WIF1 transcripts, which is considered a potential target for PC therapy.

The modular design, allowing substitution of pathway-specific components while retaining core photothermal control, extends this platform's application to diverse signaling networks, enabling selective modulation of pathways in cancer, immunity, and tissue homeostasis. By integrating spatial targeting, temporal control, and pathway-specific amplification, this technology transforms the signaling paradoxes into precise therapeutic opportunities, paving the way for precision medicine.

The present study reports four cases of pleomorphic adenoma characterised by abundant lymphoid stroma and HMGA2 rearrangements, for which transcriptomic analysis found that the lymphoid stroma shared a profile similar to that observed in lymphadenomas. Given this distinctive morphological and molecular feature, we propose the designation "lymphadenoma-like" for this novel subtype of pleomorphic adenoma.

Conversely, HMGA2::WIF1 fusions in ceruminous adenoma NOS and ceruminous pleomorphic adenoma suggest that a stromal component may not be an essential point of distinction between these groups. These residual true ceruminous adenomas all likely represent a specialized form of mixed tumor unique to the external ear.

This study investigates differentially expressed genes and pathways in hepatoblastoma, shedding light on disease mechanisms and identifying potential biomarkers for diagnosis and treatment. The findings highlight therapeutic strategies involving Wnt inhibition, ferroptosis induction, and cell cycle regulation, guiding future research into innovative treatment modalities for hepatoblastoma. Key genes CENPA, HMGA2, WIF1, DKK1, and SLC7A11 warrant further investigation due to their potential implications in hepatoblastoma tumorigenesis and proliferation. This study expands the current understanding of genetic influences of hepatoblastoma and informs future research into drivers of hepatoblastoma pathogenesis by leveraging a novel approach utilizing publicly available data.

This integrative ML-MR framework identified CHRDL1 as a robust diagnostic and functionally relevant biomarker for NSCLC. These findings offer insights into the immune-proliferative landscape of NSCLC and provide a foundation for early detection and targeted therapy strategies.

The combination EA-TMZ interacts with the Wnt pathway regulation associated with sensitizing U-87 cells, without increasing GEs of pro-inflammatory cytokines. EA deserves further investigation as an adjuvant.

By integrating spatial transcriptomics with single-cell profiling, our study generates a high-resolution atlas of the murine prostate's response to androgen deprivation. These findings provide a foundational resource for interpreting ADT responses in preclinical models of PCa.

pratense extract shows potential as an adjuvant therapy against TNBC by targeting the Wnt/β-catenin pathway and reversing EMT while enhancing DOX efficacy. Further research is warranted to explore additional anticancer mechanisms of T. pratense extract.

In addition, we defined an 11-gene signature (TYK2, IL2RG, KRT17, HLA-B, NPPC, WIF1, IL32, B2M, CCND1, CRIP1, ITGB1), which characterizes cancer cells en route to metastasis and is associated with inferior outcomes. Collectively, our findings suggest that CAFs induce pro-invasive gene expression changes involved in EMT, ECM remodeling, and migration.