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    BIOMARKER:

    WBP2 overexpression

    i
    Other names: WBP2, WW Domain Binding Protein 2, WW Domain-Binding Protein 2, WBP-2, DFNB107, GRAMD6
    Entrez ID:
    23558
    almost5years
    WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. (PubMed, Cell Death Dis)
    Through mass spectrometry, we found that WBP2 can bind to AMPKβ1, and by mutating AMPKβ1, we found that WBP2 can induce phosphorylation of AMPKβ1 at S108 and then activate the AMPK pathway to affect lipid metabolism. The effect of WBP2 on NAFLD provides a possible new direction for future research on NAFLD.
    Journal
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    WBP2 (WW Domain Binding Protein 2) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1)
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    WBP2 overexpression