Waldenstrom Macroglobulinemia

P1, N=39, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: May 2026 --> May 2027

MAS-qPCR may be a highly sensitive and cost-effective screening method for detecting MYD88 L265P and CXCR4 S338* mutations in WM.

P=N/A, N=656, Active, not recruiting, Dana-Farber Cancer Institute | Trial primary completion date: Jan 2027 --> Mar 2028

Although EMZL of the ovary and fallopian tube is rare, it should be maintained on the differential diagnosis if atypical lymphoid cells or dense lymphoid aggregates are observed in the surgical specimen.

Chemotherapy with rituximab, cyclophosphamide, and dexamethasone (RCD regimen), combined with symptomatic supportive therapy, resulted in temporary improvement of clinical symptoms and laboratory parameters. Based on relevant literature and the Chinese Expert Consensus on Diagnosis and Treatment of Lymphoplasmacytic Lymphoma (LPL)/WM (2022 Edition) [Abstract 3], this paper discusses diagnostic criteria, differentiation of pathogenic components, treatment strategies, and prognostic factors. These findings may provide clinical guidance for similar rare cases.

P2/3, N=422, Active, not recruiting, National Cancer Institute (NCI) | Suspended --> Active, not recruiting

P2, N=25, Not yet recruiting, University of Utah

P=N/A, N=50, Peking University Shenzhen Hospital; Peking University Shenzhen Hospital

To our knowledge, there have been only two cases previously described in the literature of LPL/WM involvement in the female genital tract; both of which had prominent involvement of the ovaries. Although exceedingly rare, LPL/WM involvement of the female genital tract should be considered on the differential diagnosis if atypical lymphoid cells or dense lymphoid aggregates are observed.

Expression of IRTA1 alone, or either IRTA1+ or MNDA+, was less frequent among MZL with plasma cell differentiation than among MZL with classical cell morphology (p=0.063 and 0.071, respectively), albeit not significantly. IRTA1 and MNDA are sensitive and specific markers for the differential diagnosis of MZL, and they may be helpful in distinguishing MZL from histologic mimics.