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DRUG:

VV-GMCSF-Lact

i
Other names: VV-GMCSF-Lact, Double Recombinant Vaccinia Virus VV-GMCSF-Lact
Associations
Trials
Company:
Oncostar
Drug class:
Immunostimulant, GM-CSF stimulant
Related drugs:
Associations
Trials
7ms
The Recombinant Oncolytic Virus VV-GMCSF-Lact and Chemotherapy Drugs against Human Glioma. (PubMed, Int J Mol Sci)
Testing these regimens in the U87 MG xenograft glioblastoma model confirmed this effect, as assessed by tumor growth inhibition index and histological analysis. Moreover, VV-GMCSF-Lact as monotherapy is more effective against U87 MG glioblastoma xenografts comparing temozolomide.
Journal • Oncolytic virus
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CSF2 (Colony stimulating factor 2)
|
temozolomide • VV-GMCSF-Lact
9ms
Characterizing Aptamer Interaction with the Oncolytic Virus VV-GMCSF-Lact. (PubMed, Molecules)
Thus, NV14t_56 has the ability to inhibit virus aggregation, allowing VV-GMCSF-Lact to maintain its effectiveness throughout the storage period and subsequent use. When employing aptamers as protective agents for oncolytic viruses, the presence of neutralizing antibodies should be taken into account.
Journal • Oncolytic virus
|
CSF2 (Colony stimulating factor 2)
|
VV-GMCSF-Lact
12ms
Transcriptome Changes in Glioma Cells upon Infection with the Oncolytic Virus VV-GMCSF-Lact. (PubMed, Cells)
Genes whose expression correlates with the sensitivity of cells to the virus are important for increasing the effectiveness of cancer virotherapy. Overall, the results highlight molecular markers, biological pathways, and gene networks influencing the response of glioma cells to VV-GMCSF-Lact.
Journal • Oncolytic virus • IO biomarker
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IFNG (Interferon, gamma) • CSF2 (Colony stimulating factor 2)
|
VV-GMCSF-Lact
over2years
The Signaling Pathways Controlling the Efficacy of Glioblastoma Therapy. (PubMed, Acta Naturae)
Hence, we suggest that the sensitivity of glioblastoma cells to the oncotoxic effect of VV-GMCSF-Lact is determined by the nature and extent of the disturbances in cell death regulation in various cultures. Further investigation of the factors affecting glioblastoma resistance to virotherapy will test this hypothesis and identify targets for antitumor therapy, combined with VV-GMCSF-Lact.
Journal
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CSF2 (Colony stimulating factor 2)
|
VV-GMCSF-Lact