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    BIOMARKER:

    VPREB1 deletion

    i
    Other names: VPREB1, V-Set Pre-B Cell Surrogate Light Chain 1, CD179 Antigen-Like Family Member A, Immunoglobulin Iota Chain, Pre-B Lymphocyte 1, V(Pre)B Protein, VPREB, Protein VPreB1, CD179a Antigen, VpreB Protein, CD179a, CD179A, IGVPB, VpreB, IGI
    Entrez ID:
    7441
    Related biomarkers:
    CNA
    Associations

    News

    Trials
    3ms
    Characterisation of cells markers associated with IKZF1plus in BCP-ALL. (PubMed, Transl Oncol)
    In this scenario, we found associations between IKZF1plus and certain genes in BCP-ALL, being KCNA5 and GREB1 the most promising biomarkers for predicting IKZF1plus. A deeper understanding of these genetic profiles will allow a better risk assessment and offer precise rationale for therapeutic strategies in BCP-ALL.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • IKZF1 (IKAROS Family Zinc Finger 1) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • PAX5 (Paired Box 5) • CD200 (CD200 Molecule) • BTLA (B And T Lymphocyte Associated) • SDK1 (Sidekick Cell Adhesion Molecule 1) • VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1)
    |
    CDKN2A deletion • IKZF1 deletion • VPREB1 deletion
    over2years
    Mutational Analysis of theVPREB1Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. (PubMed, J Pediatr Hematol Oncol)
    Our Bioinformatics assay results presented that these variations may alter the RNA folding, protein structure, and therefore probable effect on the protein function. These results propose that nucleotide changes probably contribute to B-ALL pathogenesis.
    Journal
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    IGH (Immunoglobulin Heavy Locus)
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    VPREB1 deletion