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    DRUG:

    VPM1002

    i
    Associations

    News

    Trials
    Company:
    Max Planck Institute, SAKK, Serum Institute of India
    Drug class:
    Immunostimulant
    Related drugs:
    Associations

    News

    Trials
    2ms
    Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants (clinicaltrials.gov)
    P3, N=6940, Completed, Serum Institute of India Pvt. Ltd. | Active, not recruiting --> Completed | Trial completion date: Dec 2025 --> Oct 2024 | Trial primary completion date: Dec 2025 --> Oct 2024
    Trial completion • Trial completion date • Trial primary completion date
    |
    VPM1002
    9ms
    Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa (clinicaltrials.gov)
    P1/2, N=0, Withdrawn, International Maternal Pediatric Adolescent AIDS Clinical Trials Group | N=480 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    VPM1002
    11ms
    Evaluation of Efficacy and Safety of VPM1002 in Comparison to BCG in Prevention of Tb Infection in Infants (clinicaltrials.gov)
    P3, N=6940, Active, not recruiting, Serum Institute of India Pvt. Ltd. | Trial primary completion date: Aug 2023 --> Dec 2025
    Trial primary completion date
    |
    VPM1002
    1year
    Study to Check the Efficacy and Safety of Recombinant BCG Vaccine in Prevention of TB Recurrence (clinicaltrials.gov)
    P2/3, N=2000, Active, not recruiting, Serum Institute of India Pvt. Ltd. | Trial completion date: Feb 2024 --> Jul 2024
    Trial completion date
    |
    VPM1002
    1year
    Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa (clinicaltrials.gov)
    P1/2, N=480, Not yet recruiting, International Maternal Pediatric Adolescent AIDS Clinical Trials Group | Trial completion date: Oct 2026 --> Jul 2027 | Trial primary completion date: Oct 2026 --> Jul 2027
    Trial completion date • Trial primary completion date
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    CD8 expression
    |
    VPM1002
    over1year
    SAKK 06/19: Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC (clinicaltrials.gov)
    P2, N=5, Recruiting, Swiss Group for Clinical Cancer Research
    Trial completion date • Trial primary completion date
    |
    cisplatin • Tecentriq (atezolizumab) • gemcitabine • VPM1002
    almost2years
    Novel sequential treatment strategy for patients with muscle-invasive bladder cancer (MIBC): intravesical recombinant BCG, followed by neoadjuvant chemoimmunotherapy, radical cystectomy plus pelvic lymphadenectomy and adjuvant immunotherapy - protocol of a multicentre, single arm phase 2 trial (SAKK 06/19). (PubMed, BMJ Open)
    Intravesical recombinant BCG (rBCG: VPM1002BC) is applied weekly for three instillations followed by four cycles of neoadjuvant cisplatin/gemcitabine every 3 weeks. Atezolizumab 1200 mg every 3 weeks is started together with rBCG and given for four cycles...Results will be made available by publication. NCT04630730.
    P2 data • Journal
    |
    PD-L1 (Programmed death ligand 1)
    |
    cisplatin • Tecentriq (atezolizumab) • gemcitabine • VPM1002
    almost5years
    Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy. (PubMed, Oncoimmunology)
    Plasma levels of TNFα significantly increased after treatment and blood-derived CD4+ T cells stimulated with PPD demonstrated significantly increased intracellular GM-CSF and IFN expression. The intravesical application of VPM1002BC is safe and well tolerated by patients and results in a potential Th1 weighted immune response.
    Clinical • P1 data • Journal
    |
    CSF2 (Colony stimulating factor 2)
    |
    CSF2 elevation • IFNA1 expression
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    VPM1002