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GENE:

VMP1 (Vacuole Membrane Protein 1)

News alerts, weekly reports and conference planners

27d

Integrative Single-Cell Analysis Reveals Targetable Vacuole Membrane Protein 1-Mediated Mechanism of Tumor Angiogenesis in Glioblastoma. (PubMed, MedComm (2020))

Treatment with bevacizumab, a monoclonal antibody against VEGFA, significantly inhibited VMP1-driven tumor growth and prolonged survival in mice. Our study thus uncovered non-autophagic functions of VMP1 as an important mediator in glioblastoma angiogenesis with the potential for therapeutic targeting.

27 days ago

Journal

VMP1 (Vacuole Membrane Protein 1)

Avastin (bevacizumab)

2ms

Luffa cylindrica flower extract induces apoptosis and autophagy in breast cancer cells. (PubMed, Pak J Pharm Sci)

LCFE exerts an anti-tumor effect by activating apoptosis and autophagy processes in breast cancer cells, while having low cytotoxicity for normal breast cells, highlighting the potential of LCFE as a natural agent for cancer treatment.

2 months ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • ATG5 (Autophagy Related 5) • BNIP3 (BCL2 Interacting Protein 3) • VMP1 (Vacuole Membrane Protein 1) • ZFP36 (ZFP36 Ring Finger Protein) • BMP4 (Bone Morphogenetic Protein 4)

7ms

Gene fusion detection in long-read transcriptome sequencing data with GFvoter. (PubMed, BMC Genomics)

Overall, our findings show that GFvoter can accurately identify gene fusions from long-read RNA-seq data, which has the potential to improve cancer diagnosis and treatment. GFvoter is available at https://github.com/xiaolan-z/GFvoter .

7 months ago

Journal

RPS6KB1 (Ribosomal Protein S6 Kinase B1) • VMP1 (Vacuole Membrane Protein 1)

7ms

Novel kinase-activating genetic events in non-small cell lung carcinomas. (PubMed, Explor Target Antitumor Ther)

ROS1, LTK, and FGFR4 high-level overexpression was observed in 1 out of 89 tumors each. This study demonstrates the scarcity of yet unknown kinase-activating alterations in NSCLCs.

7 months ago

Journal

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • FGFR4 (Fibroblast growth factor receptor 4) • LTK (Leukocyte Receptor Tyrosine Kinase) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • CLIP1 (CAP-Gly Domain Containing Linker Protein 1) • KAT6B (Lysine Acetyltransferase 6B) • VMP1 (Vacuole Membrane Protein 1)

9ms

Characteristic genes and immune infiltration analysis of gastric cancer based on bioinformatics analysis and machine learning. (PubMed, Discov Oncol)

BANF1, DUSP14, and VMP1 are promising diagnostic biomarkers for GC, and infiltrating immune cells may dramatically affect gastric carcinogenesis and progression.

9 months ago

Journal

DUSP1 (Dual Specificity Phosphatase 1) • USP14 (Ubiquitin Specific Peptidase 14) • VMP1 (Vacuole Membrane Protein 1)

11ms

Comprehensive genomic profiling reveals a unique genomic landscape in solid tumors in an Indian cancer cohort of 1000 patients: a single institutional experience. (PubMed, Sci Rep)

The overall change in therapy based on CGP in the clinical cohort was 43%, which was greater in patients enrolled for MTB than in patients who had not undergone MTB. At the interim analysis, with a median follow-up of 18 months (range 12-24 months) after the change in therapy as per genomics report, 97 patients (71%) were found to be alive thus establishing the importance of CGP and MTB in personalized genomics-driven treatment.

11 months ago

Journal • Tumor mutational burden • BRCA Biomarker • PARP Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • EML4 (EMAP Like 4) • HRD (Homologous Recombination Deficiency) • ARID1A (AT-rich interaction domain 1A) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • FGFR (Fibroblast Growth Factor Receptor) • BRCA (Breast cancer early onset) • ARID2 (AT-Rich Interaction Domain 2) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • NTRK (Neurotrophic receptor tyrosine kinase) • VMP1 (Vacuole Membrane Protein 1)

BRCA mutation

over1year

The Contribution of the Novel CLTC-VMP1 Fusion Gene to Autophagy Regulation and Energy Metabolism in Cisplatin-Resistant Osteosarcoma. (PubMed, Am J Physiol Cell Physiol)

Mouse model experiments further confirmed the promoting effect of CLTC-VMP1 on tumor growth and chemotherapy resistance. In summary, the CLTC-VMP1 gene fusion mediates energy metabolism reprogramming by regulating autophagy and apoptosis balance, which promotes chemotherapy resistance in OS.

over 1 year ago

Journal

CLTC (Clathrin Heavy Chain) • VMP1 (Vacuole Membrane Protein 1)

cisplatin

over1year

VMP1: a multifaceted regulator of cellular homeostasis with implications in disease pathology. (PubMed, Front Cell Dev Biol)

Dysregulation of VMP1 has been observed in several pathological conditions, including neurodegenerative diseases such as Parkinson's disease (PD), pancreatitis, hepatitis, and tumorogenesis, underscoring its potential as a therapeutic target. This review aims to provide an overview of VMP1's multifaceted roles and its implications in disease pathology.

over 1 year ago

Review • Journal

VMP1 (Vacuole Membrane Protein 1)

over1year

Epigenetic disease markers in primary sclerosing cholangitis and primary biliary cholangitis-methylomics of cholestatic liver disease. (PubMed, Hepatol Commun)

This study provides insights into methylation profiles of patients that support current concepts of disease mechanisms and provide novel data to inspire future research. Studies to corroborate our findings and expand into other -omics layers will be invaluable to further our understanding of these rare diseases with the goal to improve and individualize prognosis and treatment.

over 1 year ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • PSMB8 (Proteasome 20S Subunit Beta 8) • SOCS3 (Suppressor Of Cytokine Signaling 3) • VMP1 (Vacuole Membrane Protein 1)

over1year

Liposome-lentivirus for miRNA therapy with molecular mechanism study. (PubMed, J Nanobiotechnology)

These findings provide new insights in mode of action of miR-145-5p in LCSCs therapy and indicates that liposome-virus hybrid carriers hold great promise in miRNA delivery.

over 1 year ago

Journal

GLI3 (GLI Family Zinc Finger 3) • MIR145 (MicroRNA 145) • VMP1 (Vacuole Membrane Protein 1)

almost2years

Decoding the Versatile Landscape of Autophagic Protein VMP1 in Cancer: A Comprehensive Review across Tissue Types and Regulatory Mechanisms. (PubMed, Int J Mol Sci)

Additionally, this article discusses VMP1 gene fusions, especially with ribosomal protein S6 kinase B1 (RPS6KB1), shedding light on potential implications for tumor malignancy. By deciphering the molecular mechanisms linking VMP1 to cancer progression, this exploration paves the way for innovative therapeutic strategies to disrupt these pathways and potentially improve treatment outcomes.

almost 2 years ago

Review • Journal

KRAS (KRAS proto-oncogene GTPase) • MIR21 (MicroRNA 21) • RPS6KB1 (Ribosomal Protein S6 Kinase B1) • RPS6 (Ribosomal Protein S6) • MIR210 (MicroRNA 210) • VMP1 (Vacuole Membrane Protein 1)