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    DRUG CLASS:

    Viral replication inhibitor

    Related drugs:
    3ms
    A Study to Learn How Paxlovid [Nirmatrelvir-ritonavir/PF-07321332] Works in COVID-19 Patients Who Are Elderly or Have Medical Conditions. (clinicaltrials.gov)
    P=N/A, N=99000, Completed, Pfizer | Active, not recruiting --> Completed
    Trial completion • Real-world evidence
    3ms
    A Study to Learn About Effects of Living With COVID-19 and the Use of the Medicines Nirmatrelvir-Ritonavir in Treating COVID-19. (clinicaltrials.gov)
    P=N/A, N=2315187, Completed, Pfizer | N=8252912 --> 2315187
    Enrollment change • HEOR • Real-world evidence
    4ms
    Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous (clinicaltrials.gov)
    P3, N=6, Completed, Centre Hospitalier Universitaire de Nice | Unknown status --> Completed
    Trial completion
    4ms
    Study of TRX-100 Tablets Evaluating the Safety, Pharmacokinetics, and Food Effect in Healthy Volunteers (clinicaltrials.gov)
    P1, N=24, Recruiting, Traws Pharma, Inc. | Not yet recruiting --> Recruiting | N=16 --> 24
    Enrollment open • Enrollment change • Trial initiation date
    4ms
    Using activity-based protein profiling method to explore the antitumor targets of spiramycin derivatives (PubMed, Se Pu)
    Carrimycin is a macrolide antibiotic widely used in the pharmaceutical and clinical fields， with its primary composition consisting of three distinct derivatives of spiramycin...This work effectively advances spiramycin derivatives from compounds with observed phenotypic activity toward agents with an emerging mechanistic understanding， thereby paving the way for more targeted drug design and informed combination therapy strategies in oncology. Future studies will focus on delineating the detailed downstream consequences of APP engagement by h-SPM and exploring the therapeutic potential of other identified targets in preclinical models.
    Journal
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    APP (Amyloid Beta Precursor Protein)
    |
    carrimycin
    5ms
    SHIELD: SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (clinicaltrials.gov)
    P2, N=150, Not yet recruiting, Icahn School of Medicine at Mount Sinai
    New P2 trial
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    valacyclovir
    5ms
    GV1001, hTERT Peptide Fragment, Prevents 5-Fluorouracil-Induced Mucositis by Inhibiting Mitochondrial Damages. (PubMed, Cells)
    GV1001 markedly mitigated these 5-FU-induced mitochondrial defects. Taken together, GV1001 mitigates CIM by most likely preserving mitochondrial integrity and function, supporting its potential as a strategy to prevent cancer chemotherapy-associated mucosal injury in patients.
    Journal
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    TERT (Telomerase Reverse Transcriptase)
    |
    5-fluorouracil • LucaVax (tertomotide)
    5ms
    ZELA: Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD) (clinicaltrials.gov)
    P2/3, N=366, Recruiting, Airway Therapeutics, Inc. | N=241 --> 366
    Enrollment change
    5ms
    Scripps-eMed Covid-19 Study: A Prospective Monitoring Study for Those Individuals Treated With Paxlovid (clinicaltrials.gov)
    P=N/A, N=917, Completed, Scripps Translational Science Institute | Enrolling by invitation --> Completed
    Trial completion
    5ms
    Efficacy and safety of combination therapy with eravacycline versus the Best Available Treatment in patients with severe infection in the department of hematology: a multicenter retrospective study (ChiCTR2600120570)
    P=N/A, N=350, Recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University o
    New trial
    5ms
    Deuremidevir Hydrobromide Tablets (VV116) Clinical Application Demonstration Project for the Treatment of SARS-CoV-2 Infection (ChiCTR2600120129)
    P=N/A, N=3347, Shanghai Public Health Clinical Center; Shanghai Public Health Clinical Center
    New trial
    6ms
    Study of TRX-100 Tablets Evaluating the Safety, Pharmacokinetics, and Food Effect in Healthy Volunteers (clinicaltrials.gov)
    P1, N=24, Recruiting, Traws Pharma, Inc.
    New P1 trial