vinblastine

Furthermore, treatment with AVD (adriamycin/vinblastine/dacarbazine) in combination with brentuximab vedotin (BV) was initiated to achieve a complete metabolic response. Histopathologically, SV has a high proportion of HRS cells, with high CD30-positive and low EBER-positive rates. Therefore, CD30-targeted therapies such as BV may be preferable for SV, even in localized NS-HL patients, thereby improving patient prognosis.

This study establishes PHF19 as a potential prognostic indicator and immunotherapy target in PCPG, highlighting its immunomodulatory potential and the need to validate its therapeutic value functionally. Subsequent studies should focus on corroborating these results in broader cohorts and on probing the therapeutic prospects of targeting PHF19 in PCPG.

P1/2, N=63, Active, not recruiting, Centre Oscar Lambret | Trial primary completion date: May 2025 --> Dec 2025

P1/2, N=50, Recruiting, St. Justine's Hospital | Not yet recruiting --> Recruiting

Drug sensitivity analysis revealed that high DDR1 expression was associated with reduced sensitivity to methotrexate but increased sensitivity to vinblastine, doxorubicin, cisplatin, and docetaxel, with no significant difference observed for gefitinib. IHC of clinical samples confirmed DDR1 overexpression in 55.88% of NSCLC patients. Our study demonstrated that DDR1 promotes tumor progression and immune evasion and is frequently overexpressed in NSCLC patients, suggesting that DDR1 is a potential prognostic biomarker and therapeutic target.

A key finding from drug sensitivity analysis was that the high-risk group exhibited significantly increased sensitivity to several drugs, including CCT018159, rapamycin, vinblastine, metformin, and roscovitine. Moreover, the expression levels of SESN3, CRIP1, DPP4 and PIK3CA were significantly upregulated in breast cancer samples compared to control samples. This study constructed a risk model based on seven prognostic genes, offering new potential strategies for breast cancer therapy.

Ultimately, the application of tryptophan at concentration 250 ppm was effective in alleviating the adverse impacts of drought stress by enhancing dry weight, photosynthetic pigments, and antioxidant enzyme activities in the periwinkle plant, culminating in increases in vincristine and vinblastine levels by 193% and 138%, respectively, under severe drought stress (40% field capacity).

P2, N=54, Recruiting, National Medical Research Radiological Centre of the Ministry of Health of Russia | Trial completion date: Jan 2032 --> Jan 2029 | Trial primary completion date: Jan 2029 --> Jan 2028

This study establishes a PANoptosis-derived prognostic model with moderate but consistent prognostic utility across platforms, underscoring its potential research value. By linking PRGs to risk stratification and immune heterogeneity, the model provides insights into PANoptosis biology and supports future exploration of personalized immunotherapy in cervical cancer.

However, these cells are also more sensitive to losing this stable MT fraction, notably upon exposure to MTA vinblastine...Interestingly, wound-healing assays suggest Runx2-deficient OBs possess enhanced migratory capacity under both basal conditions and following MT disruption. Altogether, these findings uncover a novel role for Runx2 in regulating MT dynamics and suggest that, in specific contexts, Runx2 may suppress OB migration.

P2, N=20, Active, not recruiting, New York Medical College | Not yet recruiting --> Active, not recruiting

These findings demonstrated that Epichloe festucae is a promising microbial platform for the sustainable production of vinblastine and vincristine, offering a potential alternative to plant-derived sources for commercial and pharmaceutical applications. The online version contains supplementary material available at 10.1007/s13205-025-04562-5.