vinblastine

Ultimately, the application of tryptophan at concentration 250 ppm was effective in alleviating the adverse impacts of drought stress by enhancing dry weight, photosynthetic pigments, and antioxidant enzyme activities in the periwinkle plant, culminating in increases in vincristine and vinblastine levels by 193% and 138%, respectively, under severe drought stress (40% field capacity).

P2, N=54, Recruiting, National Medical Research Radiological Centre of the Ministry of Health of Russia | Trial completion date: Jan 2032 --> Jan 2029 | Trial primary completion date: Jan 2029 --> Jan 2028

This study establishes a PANoptosis-derived prognostic model with moderate but consistent prognostic utility across platforms, underscoring its potential research value. By linking PRGs to risk stratification and immune heterogeneity, the model provides insights into PANoptosis biology and supports future exploration of personalized immunotherapy in cervical cancer.

However, these cells are also more sensitive to losing this stable MT fraction, notably upon exposure to MTA vinblastine...Interestingly, wound-healing assays suggest Runx2-deficient OBs possess enhanced migratory capacity under both basal conditions and following MT disruption. Altogether, these findings uncover a novel role for Runx2 in regulating MT dynamics and suggest that, in specific contexts, Runx2 may suppress OB migration.

P2, N=20, Active, not recruiting, New York Medical College | Not yet recruiting --> Active, not recruiting

These findings demonstrated that Epichloe festucae is a promising microbial platform for the sustainable production of vinblastine and vincristine, offering a potential alternative to plant-derived sources for commercial and pharmaceutical applications. The online version contains supplementary material available at 10.1007/s13205-025-04562-5.

Notably, the 50% inhibitory concentration (IC50) values of axitinib and sunitinib were significantly higher in Caki/AX cells than those in Caki-2 cells, indicating 2.83- and 1.2-fold resistance, respectively. By contrast, the IC50 values of sorafenib and erlotinib were decreased in Caki/AX cells. Moreover, Caki/AX cells showed resistance to everolimus, temsirolimus and rapamycin, and decreased sensitivity to vinblastine, vincristine, paclitaxel, doxorubicin and SN-38 compared with Caki-2 cells. Notably, etoposide, 5-fluorouracil, cisplatin and carboplatin sensitivities were comparable in both cell types...A PCR array related to vascular endothelial growth factor signalling showed that the mRNA levels of FIGF (also known as vascular endothelial growth factor D) and sphingosine kinase 1 were upregulated, whereas those of Rac family small GTPase 2 were downregulated in Caki/AX cells. Overall, these findings suggested that the upregulation of the ATP-binding cassette subfamily B member 1, FIGF and sphingosine kinase 1 mRNA levels, and downregulation of the Rac family small GTPase 2 mRNA levels may contribute to acquired resistance in Caki/AX cells.

Bone marrow biopsy revealed lymphoma infiltration, prompting initiation of A+AVD (brentuximab vedotin, doxorubicin, vinblastine, dacarbazine) chemotherapy for stage IV disease based on Karnofsky Performance Status...Treatment depends on disease stage, with early stage managed by ABVD (Adriamycin, Bleomycin sulfate, Vinblastine sulfate, Dacarbazine) chemotherapy and radiation, while advanced cases require extended A+AVD chemotherapy. PPL accounts for <2% of extra-nodal lymphomas but remains a potentially treatable entity. This case underscores the importance of obtaining tissue diagnosis in the setting of a pancreatic mass before embarking on definitive treatment.

P3, N=500, Completed, University Hospital, Rouen | Active, not recruiting --> Completed

P2, N=82, Active, not recruiting, Academic and Community Cancer Research United | Trial completion date: Jul 2025 --> Jul 2026 | Trial primary completion date: Jul 2022 --> Jul 2025

P1/2, N=50, Not yet recruiting, St. Justine's Hospital | Trial completion date: Apr 2035 --> Apr 2033 | Initiation date: Apr 2025 --> Dec 2025

These findings highlight the complexity of chemoresistance mechanisms. The characterized cell line panel represents a valuable resource for future studies aimed at understanding and overcoming drug resistance in bladder cancer, suggesting that personalized therapeutic approaches may be necessary.