VIM (Vimentin)

Clinically, the case was challenging because it mimicked a non-neoplastic proliferative process and, microscopically, presented as an amelanotic variant. An immunohistochemical panel is recommended to avoid diagnostic pitfalls; this is the first report of TRP-2 immunoexpression in oral amelanotic melanoma.

This study demonstrates the impact of microenvironmental stiffness on breast cancer cell phenotype and highlights 3D GelMA hydrogels as a platform to investigate tumour microenvironment dynamics. The findings provide insights into how matrix stiffness influences EMT and breast cancer behaviour in biomimetic settings.

Small molecule inhibitors such as RSL3 and ML210 trigger ferroptosis by targeting glutathione peroxidase 4 (GPX4), a key enzyme that neutralizes lipid peroxides. Tumors derived from GPX4i-resistant cells compared to parental cells had unique metabolic and lipidomic profiles, were associated with a shift toward an epithelial-like state (decreased vimentin, increased EpCAM expression), formed decreased spontaneous metastases from primary tumors, but had no differences in overall metastatic burden upon intravenous injection. Collectively, these data demonstrate that long-term maintenance with GPX4-inhibitors in vitro leads to altered metastatic profiles in vivo.

Our findings identify Cx32 cell-cell communication as suppressing migratory and proliferative behaviours in normal urothelial differentiation and suggest that Cx32 assessment, within the context of luminal muscle-invasive bladder cancer, can predict more invasive biology. This reveals the potential for differentiated cancers to exhibit EMT.

A literature review revealed very few documented instances of SR in oral malignancies, often following diagnostic procedures, potentially due to biopsy-induced immune activation and alterations in the tumour microenvironment. This case underscores the enigmatic nature of SR in oral cancers and highlights the need for long-term surveillance, while raising important considerations about immune mechanisms and their potential therapeutic implications in head and neck oncology.

Histopathology and immunohistochemistry are the best myoepithelioma diagnostic methods. Malignant myoepithelioma must be ruled out by thorough invasion testing.

Pembrolizumab was initiated, but disease progression ultimately occurred after several months, accompanied by functional decline...Endobronchial metastasis should be considered in patients with a remote history of melanoma presenting with new respiratory symptoms. Prompt diagnosis through bronchoscopy and immunohistochemistry enables timely implementation of palliative and supportive management.

Inhibition of the FoxM1/Snail/EMT pathway reversed PKMYT1-induced metastasis in mice. Collectively, our findings identify the PKMYT1/FoxM1/Snail axis as a driver of ccRCC metastasis via EMT induction, highlighting PKMYT1 as a potential therapeutic target for ccRCC.

Immunohistochemically, neoplastic stromal cells were immunolabeled for glial fibrillary acidic protein (GFAP), neuron specific antigen (NSE), and vimentin, and capillary endothelia and vessel walls were immunolabeled for CD31 and smooth muscle actin (SMA). Postoperative follow-up revealed improvements in neurological symptoms and no evidence of tumor recurrence for 3 months to 3 years, suggesting that surgical excision is a beneficial treatment method.

Notably, restoring SCN4B levels suppressed LUAD cell viability, migration and invasion in vitro, accompanied by inhibition of EMT. These findings highlighted SCN4B as a potential tumor suppressor and a promising therapeutic target for LUAD.

Accurate diagnosis relies on careful histopathologic evaluation and exclusion of histologic mimickers using a comprehensive immunohistochemical panel. Complete surgical excision remains the cornerstone of treatment, and long-term follow-up is recommended due to the tumor's intermediate malignant potential.

This study provides the first detailed protocol for establishing primary CMG epithelial cultures and validates their suitability as a reference model for future oncological studies. Overall, this platform supports translational research, including drug testing and biomarker discovery, contributes to personalized veterinary therapies and enhanced understanding of mammary gland pathology in both dogs and humans.