News - VIM expression

Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models. (PubMed, Sci Rep)

Altogether, these results demonstrated that TiY has a strong potential for visualizing CRC by fluorescence imaging in various preclinical models, which can be further translated for clinical use such as fluorescence-guided surgery. Furthermore, our data indicate that TiY is preferentially uptaken by cells with EMT induction and progression, and overexpressing vimentin and Zeb1 in patients with CRC.

4 days ago

Preclinical • Journal

VIM (Vimentin) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

VIM expression • ZEB1 expression

miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma by Regulating CDT1 (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban)

Nude mice in vivo experiments showed that miR-2110 overexpression significantly decreased the expression of Ki67, a tumor proliferation index, and vimentin and MMP9, two metastasis indices, compared with the control group. miR-2110 can inhibit proliferation and metastasis of LUAD by targeting CDT1, providing a new rationale for the treatment of LUAD.

8 days ago

Journal

VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9) • CDT1 (Chromatin Licensing And DNA Replication Factor 1)

VIM expression • miR-211 expression

Analysis of Clinicopathological Characteristics and Factors Affecting the Prognosis of Patients With Resectable Sarcomatoid Carcinoma of the Bladder (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban)

In the RC group, tumor multiplicity, age ≥75 years, and lack of postoperative adjuvant therapy are independent risk factors for overall survival. Female sex is an independent risk factor affecting prognosis in the BPS group.

8 days ago

Retrospective data • Journal

HER-2 (Human epidermal growth factor receptor 2) • VIM (Vimentin)

VIM expression

DDX5-Targeting Fragile X Mental Retardation Protein Regulates the Wnt/β-catenin Signaling Pathway to Promote Epithelial Mesenchymal Transition in Breast Cancer (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban)

The regulatory effect of FMRP on DDX5 protein expression was assessed using the protein synthesis inhibitor cycloheximide (CHX) and proteasome inhibitor MG132...On the other hand, the expression of these proteins was reversed by combined FMRP overexpression (P<0.05). FMRP targets DDX5 and promotes BC cell migration and EMT via the activation of the Wnt/β-catenin signaling pathway.

8 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • DDX5 (DEAD-Box Helicase 5) • SNAI2 (Snail Family Transcriptional Repressor 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

MYC expression • CDH1 expression • VIM expression • ZEB1 expression

MG132

Role of Abelson interactor 2 in progression and prognosis of gastric cancer and its regulatory mechanisms (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)

ABI2 is highly expressed in gastric cancer, which affects long-term prognosis of the patients, possible due to its regulatory effect on Wnt signaling to promote proliferation, migration and invasion of gastric cancer cells.

8 days ago

Journal

CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • WNT2 (Wnt Family Member 2)

CDH1 expression • VIM expression

Disabled 2 (Dab2) Regulates Tumour Progression in Skin Squamous Cell Carcinoma. (PubMed, Exp Dermatol)

We generated tamoxifen inducible Dab2 conditional knockout system for our study...In patients, TCGA data analysis of skin cancer melanoma (SKCM) showed a trend where high levels of Dab2 correlated with poor overall survival. The present study shows that Dab2 promotes tumour progression in skin SCC.

9 days ago

Journal

SOX2 • VIM (Vimentin) • TWIST1 (Twist Family BHLH Transcription Factor 1) • DAB2 (DAB Adaptor Protein 2)

VIM expression • SOX2 expression

tamoxifen

The Expression Levels of Transforming Growth Factor β1 and Tumor Necrosis Factor Receptor Associated Factor 6 in Allergic Rhinitis Patients and Their Potential Relationship with Epithelial - Mesenchymal Transition: A Pilot Prospective Observational Study. (PubMed, J Asthma Allergy)

TGF-β1, TRAF6, and EMT-related markers (Vimentin, α-SMA) were highly expressed in the nasal mucosa of AR patients. TGF-β1 and TRAF6 may be involved in the epithelial-mesenchymal transition in allergic rhinitis.

9 days ago

Observational data • Journal

TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • VIM (Vimentin) • TGFB1 (Transforming Growth Factor Beta 1) • TRAF6 (TNF Receptor Associated Factor 6)

CDH1 expression • VIM expression

10d

Comprehensive liquid biopsy analysis for monitoring NSCLC patients under second-line osimertinib treatment. (PubMed, Front Oncol)

AXL and PIM-1 expression detected in CTCs during treatment suggesting new possible therapeutic strategies. Our results reveal that comprehensive liquid biopsy analysis can efficiently represent the heterogeneous molecular landscape and provide prominent information on subsequent treatments for NSCLC patients at PD since druggable molecular alterations were detected in CTCs.

10 days ago

Journal • Liquid biopsy • PD(L)-1 Biomarker • IO biomarker • Biopsy

EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MET (MET proto-oncogene, receptor tyrosine kinase) • AXL (AXL Receptor Tyrosine Kinase) • B2M (Beta-2-microglobulin) • FOXA1 (Forkhead Box A1) • PIM1 (Pim-1 Proto-Oncogene) • VIM (Vimentin) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • KRT19 (Keratin 19) • RASSF1 (Ras Association Domain Family Member 1) • WIF1 (WNT Inhibitory Factor 1) • BRMS1 (BRMS1 Transcriptional Repressor And Anoikis Regulator)

PD-L1 expression • BRAF V600E • KRAS mutation • EGFR mutation • KRAS G12C • HER-2 amplification • PIK3CA mutation • BRAF V600 • MET amplification • EGFR T790M • MET mutation • KRAS G12 • EGFR mutation + PIK3CA mutation • HER-2 amplification + PD-L1 expression • VIM expression • HER-2 amplification + MET amplification • RASSF1 methylation

Tagrisso (osimertinib)

11d

Metformin as a Potential Therapeutic Agent in Breast Cancer: Targeting miR-125a Methylation and Epigenetic Regulation. (PubMed, Int J Mol Cell Med)

Metformin may serve as a targeted therapeutic agent in HER2-positive breast cancer by modulating the miR-125a-HER2 axis and influencing on the epigenetic and EMT regulation. Further research is warranted to elucidate the therapeutic potential of metformin through these mechanisms.

11 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • DNMT1 (DNA methyltransferase 1) • VIM (Vimentin) • MIR125A (MicroRNA 125a)

HER-2 positive • VIM expression • DNMT1 expression

metformin

11d

A potential target of GXYLT2 affecting the prognosis of gastric cancer by enhancing the EMT process: A clinical retrospective study. (PubMed, Oncol Lett)

In conclusion, GXYLT2 may be related to the pathogenesis of GC, and its abnormal expression could be associated with epithelial-mesenchymal transition. Consequently, GXYLT2 may be considered a promising prognostic marker in the context of GC.

11 days ago

Retrospective data • Journal

NOTCH1 (Notch 1) • CDH1 (Cadherin 1) • VIM (Vimentin)

CDH1 expression • NOTCH1 expression • VIM expression

11d

Clinical and histopathological features of advanced cutaneous squamous cell carcinoma with varying responses to cemiplimab. (PubMed, J Dtsch Dermatol Ges)

Cemiplimab is a safe and effective therapy, particularly in elderly patients. Well-differentiated tumors with low proliferative index, intratumoral inflammatory infiltrate, and tumor necrosis may predict better clinical response.

11 days ago

Journal • PD(L)-1 Biomarker • Metastases

CDH1 (Cadherin 1) • VIM (Vimentin)

CDH1 expression • VIM expression

Libtayo (cemiplimab-rwlc)

14d

Label-based comparative proteomics of oral mucosal tissue to understand progression of precancerous lesions to oral squamous cell carcinoma. (PubMed, Biochem Biophys Rep)

The differentially expressed proteins provide insights into the molecular mechanisms underlying the progression of oral premalignant lesions to malignant phenotypes. The study has translational value for early detection, risk stratification, and potential therapeutic targeting of oral premalignant lesions and in its prevention to malignant forms.

14 days ago

Journal

VIM (Vimentin) • ANXA7 (Annexin A7) • COL6A2 (Collagen Type VI Alpha 2 Chain)

VIM expression

14d

Conversion of glioma cells into neuron-like cells by small molecules. (PubMed, iScience)

Additionally, SLCDS inhibits the expressions of EGFR, PDGFR, Ki67, and Vimentin in gliomas. Our findings offer a potential approach for treating glioma.

14 days ago

Journal

EGFR (Epidermal growth factor receptor) • SOX2 • VIM (Vimentin) • NEUROD1 (Neuronal Differentiation 1)

EGFR expression • VIM expression

14d

Histopathological diagnosis of pulmonary sclerosing pneumocytoma in needle biopsy specimens (PubMed, Zhonghua Bing Li Xue Za Zhi)

The useful clues include presence of cellular papillae, mild cellular atypia, morphological diversity, interstitial foam-like cell aggregates, and prominent background hemorrhage and sclerosis. The characteristic immunophenotype and middle-aged female predilection are also helpful for the diagnosis of PSP.

14 days ago

Retrospective data • Journal • Biopsy

TTF1 (Transcription Termination Factor 1) • NKX2-1 (NK2 Homeobox 1) • VIM (Vimentin) • NAPSA (Napsin A Aspartic Peptidase)

PGR expression • VIM expression • NKX2-1 expression • TTF1 expression

15d

The relationship between TMCO1 and CALR in the pathological characteristics of prostate cancer and its effect on the metastasis of prostate cancer cells. (PubMed, Open Life Sci)

In addition, CALR recombinant protein upregulated the expression of epithelial-mesenchymal transition marker, Vimentin, Conversely, knockout of TMCO1 significantly reduced the expression of CALR and Vimentin. Knockout of TMCO1 can reverse the effect of CALR recombinant protein, elucidating the pivotal roles of TMCO1 and CALR in the regulation of prostate cancer metastasis through modulation of calcium homeostasis.

15 days ago

Journal

VIM (Vimentin) • CALR (Calreticulin)

VIM expression

17d

A novel 3D cardiac microtissue model for investigation of cardiovascular complications in rheumatoid arthritis. (PubMed, Stem Cell Res Ther)

The cMTs model may represent an advanced human stem cell-based platform for modeling CV complications in RA. The highly developed capillary-like structures observed within RA cMTs highlight a critical feature of inflammation-induced CV dysfunction in chronic inflammatory diseases.

17 days ago

Journal

VIM (Vimentin) • CD31 (Platelet and endothelial cell adhesion molecule 1) • DDR2 (Discoidin domain receptor 2) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • CDH5 (Cadherin 5) • MYH7 (Myosin Heavy Chain 7)

CD31 expression • VIM expression

17d

Bone sialoprotein facilitates anoikis resistance in lung cancer by inhibiting miR-150-5p expression. (PubMed, J Cell Mol Med)

Knockdown of BSP expression was shown to block lung cancer metastasis by lowering anoikis resistance in vivo. These results indicate that BSP is a promising target to deal with anoikis resistance and metastasis in human lung cancers.

17 days ago

Journal

CDH1 (Cadherin 1) • VIM (Vimentin) • MIR150 (MicroRNA 150) • MMP14 (Matrix Metallopeptidase 14)

CDH1 expression • VIM expression

18d

The impact of ERP29 on the progression of pharyngeal squamous cell carcinoma. (PubMed, Sci Rep)

Here, we investigated ERP29 impact on PSCC progression in cisplatin (CDDP)-sensitive (FaDu and LAU-2063), CDDP-treated (FaDu-CDDP), and CDDP-resistant (FaDu-R) cells...Lower ERP29 and higher miR-4421 expressions were predictive of poor survival, suggesting a potential therapeutic use for miR-4421 inhibitors. Upon validation, these findings may contribute to targeted therapies for PSCC based on ensuring ERP29 expression.

18 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CCNE1 (Cyclin E1) • MDM2 (E3 ubiquitin protein ligase) • CDH1 (Cadherin 1) • MAPK1 (Mitogen-activated protein kinase 1) • VIM (Vimentin) • CASP9 (Caspase 9) • JUN (Jun proto-oncogene) • SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1)

CDH1 expression • VIM expression

cisplatin

18d

Restoration of miR-451a-5p/miR-34a-5p could suppress the proliferation and migration of human breast cancer cells through Wnt/β- catenin and ERK/P-ERK signaling pathways. (PubMed, Arch Razi Inst)

Therefore, the simultaneous restoration of the presented tumor suppressor miRNAs can be proposed as a valuable and potential therapeutic strategy in the treatment of breast cancer. However, further studies should be useful.

18 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CASP3 (Caspase 3) • MIR34A (MicroRNA 34a-5p) • VIM (Vimentin) • CASP8 (Caspase 8) • MMP9 (Matrix metallopeptidase 9) • MIR451A (MicroRNA 451a)

VIM expression

18d

RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial-mesenchymal transition. (PubMed, Cancer Metab)

RHOF plays an oncogenic role in PC. c-Myc is upregulated by RHOF and promotes PKM2 transcription. PKM2 further induces glycolysis, and the lactate produced by glycolysis causes the lactylation of Snail1, ultimately promoting EMT.

18 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • LDHA (Lactate dehydrogenase A) • CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • SNAI1 (Snail Family Transcriptional Repressor 1) • PKM (Pyruvate Kinase M1/2)

CDH1 expression • VIM expression

18d

Targeted dynamic phospho-proteogenomic analysis of gastric cancer cells suggests host immunity provides survival benefit. (PubMed, Mol Cell Proteomics)

Using a reverse-phase protein array-based proteogenomic analysis of a panel of eight GC cell lines, we identified genetic alterations and signaling pathways, potentially associated with resistance to DNA-damaging drugs, including 5-fluorouracil (5FU), cisplatin, and etoposide. Moreover, TLC+ patients who had no survival benefit from adjuvant chemotherapy were discriminated by expression of IκBα, a potent negative regulator of NFκB. Collectively, our results suggest that 5FU resistance observed in cell lines may be overcome by host immunity or by combination therapy with immune checkpoint blockade.

18 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • VIM (Vimentin) • NFKBIA (NFKB Inhibitor Alpha 2)

PD-L1 expression • VIM expression

cisplatin • 5-fluorouracil • etoposide IV

21d

Is Immunohistochemical Galectin-3 Expression Associated with the Epithelial-Mesenchymal Transition in High- and Low-Grade Invasive Urothelial Carcinomas of the Bladder? (PubMed, Diagnostics (Basel))

However, the decrease in its expression in advanced stages underscores the need for further research to understand its multifaceted involvement in bladder cancer. These findings suggest that while galectin-3 may contribute to the EMT and early tumor progression, its exact role and potential as a therapeutic target require more detailed investigation.

21 days ago

Journal

CDH1 (Cadherin 1) • VIM (Vimentin) • LGALS3 (Galectin 3)

CDH1 expression • VIM expression

21d

Allicin Ameliorated High-glucose Peritoneal Dialysis Solution-induced Peritoneal Fibrosis in Rats via the JAK2/STAT3 Signaling Pathway. (PubMed, Cell Biochem Biophys)

The ability of allicin to inhibit fibrosis and the EMT process was significantly attenuated after HPMCs were treated with colivelin. Taken together, these findings suggest that allicin inhibits inflammation and EMT, thereby improving PF, and this protective effect may be achieved by inhibiting the JAK2/STAT3 signaling pathway.

21 days ago

Preclinical • Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • VIM (Vimentin) • CCL2 (Chemokine (C-C motif) ligand 2) • TGFB1 (Transforming Growth Factor Beta 1) • CDH2 (Cadherin 2) • IL1B (Interleukin 1, beta)

CDH1 expression • VIM expression

22d

DCLK1 mediated cooperative acceleration of EMT by avian leukosis virus subgroup J and Marek's disease virus via the Wnt/β-catenin pathway promotes tumor metastasis. (PubMed, J Virol)

Exploring the molecular mechanisms by which ALV-J and MDV cooperate during EMT will contribute to our understanding of tumor progression and metastasis. This study provides new insights into the cooperative induced tumor metastasis by retroviruses and herpesviruses.

22 days ago

Journal

MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • TCF4 (Transcription Factor 4)

CDH1 expression • VIM expression

22d

The simultaneous miR-155-5p overexpression and miR-223-3p inhibition can activate pEMT in oral squamous cell carcinoma. (PubMed, J Appl Oral Sci)

miR-223-3p inhibits the migration of OSCC cells, while miR-155-5p can elevate the miR-223-3p mRNA expression. The simultaneous miR-155-5p overexpression and miR-223-3p inhibition can activate pEMT, increasing OSCC migration in vitro. This provides a novel approach and potential target for the effective treatment of OSCC.

22 days ago

Journal

CDH1 (Cadherin 1) • MIR155 (MicroRNA 155) • VIM (Vimentin) • CDH2 (Cadherin 2) • CTNND1 (Catenin Delta 1) • MIR223 (MicroRNA 223)

CDH1 expression • miR-155 overexpression • VIM expression • miR‐223 overexpression

23d

Expression of Markers Associated with Epithelial-Mesenchymal Transition and Extracellular Matrix Degradation in Human Uveal Melanoma. (PubMed, Bull Exp Biol Med)

The ratio of MMP-9 to TIMP-1 proteins related to the extracellular matrix degradation was higher in the tumor. These results may indicate activation of EMT-like process in the uveal melanoma cells and degradation of the extracellular matrix, which can contribute to the development of collective invasion in uveal melanoma.

23 days ago

Journal

CDH1 (Cadherin 1) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9)

CDH1 expression • VIM expression

24d

Molecular alterations of podocytes in primary focal segmental glomerulosclerosis and IgA nephropathy. (An exploratory study) (PubMed, Arkh Patol)

Bidirectional alterations in the glomerular expression of WT1 and intermediate filament proteins are apparent in pFSGS and IgAN. These findings are suggestive for the genomic reprogramming of podocytes and the parietal epithelium of the glomerulus as part of the epithelial-mesenchymal transition, determining the structural and functional disorders of these cells, more prominent in pFSGS.

24 days ago

Journal

WT1 (WT1 Transcription Factor) • VIM (Vimentin)

VIM expression

24d

Cervical angiofibroma of soft tissue: A rare case report with literature review. (PubMed, Medicine (Baltimore))

Cervical angiofibroma of soft tissue is a rare tumor with a benign clinical manifestation, minimal local recurrence, and no significant metastatic potential. Treatment primarily involves local resection with a focus on achieving negative surgical margins. By presenting this case, we aim to enhance the diagnostic and differential diagnostic capabilities of pathologists in identifying uterine tumors and preventing misdiagnosis.

24 days ago

Review • Journal

ER (Estrogen receptor) • TP53 (Tumor protein P53) • PGR (Progesterone receptor) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD163 (CD163 Molecule) • CD34 (CD34 molecule) • VIM (Vimentin) • CD68 (CD68 Molecule) • MME (Membrane Metalloendopeptidase) • STAT6 (Signal transducer and activator of transcription 6)

TP53 expression • VIM expression

28d

TROP2 Expression and Therapeutic Implications in Cutaneous Squamous Cell Carcinoma: Insights From Immunohistochemical and Functional Analysis. (PubMed, Exp Dermatol)

Knockdown of TROP2 also resulted in decreased expression of vimentin, along with reduced migratory capacity. These findings suggest that TROP2 plays a crucial role in cSCC cell proliferation and migration, and highlight the potential of sacituzumab govitecan as a promising therapeutic option for cSCC.

28 days ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • VIM (Vimentin) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)

TROP2 expression • BCL2 expression • CCND1 expression • VIM expression

Trodelvy (sacituzumab govitecan-hziy)

28d

Mesenchymal-type genetic mutations are likely pre-requisite for glioblastoma multiforme to metastasize outside the central nervous system: an original case series and systematic review of the literature. (PubMed, World Neurosurg)

In sum, there is strong evidence that GBMs acquire novel mutations to survive outside the CNS. In some cases, tumor cells likely mutate after seeding scalp tissue during surgery, and in others, they mutate and spread without surgery. Future studies and genetic profiling of primary and metastatic lesions may help uncover the mechanisms of spread.

28 days ago

Review • Journal • Metastases

TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • NF1 (Neurofibromin 1) • TERT (Telomerase Reverse Transcriptase) • CDK4 (Cyclin-dependent kinase 4) • VIM (Vimentin)

TP53 mutation • PTEN mutation • NF1 mutation • TERT mutation • VIM expression • CDK4 mutation

28d

siLOXL2 inhibits endothelial inflammatory response and EndMT induced by Ox-LDL. (PubMed, Cerebrovasc Dis Extra)

LOXL2 silencing is protected against ox-LDL-induced endothelial cell dysfunction, and the mechanism may be related to the inhibition of the EndMT pathway.

28 days ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • ICAM1 (Intercellular adhesion molecule 1) • VIM (Vimentin) • CD31 (Platelet and endothelial cell adhesion molecule 1) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • TERC (Telomerase RNA Component) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CAT (Catalase) • LOXL2 (Lysyl Oxidase Like 2)

VEGFA expression • VIM expression

29d

Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway. (PubMed, Cancer Med)

Knockdown of Serinc2 inhibited the malignant progression of CC, which was achieved via Myc pathway. Our study provides novel insight into CC pathogenesis.

29 days ago

Journal

MYC expression • CDH1 expression • VIM expression

29d

TRAF4 promotes lung cancer development by activating tyrosine kinase of EGFR (PubMed, Zhonghua Zhong Liu Za Zhi)

TRAF4 expression is elevated in NSCLC tissues and tumor cells, which promotes tumor proliferation, migration and invasion. TRAF4 directly binds to EGFR molecules, enhances its own phosphorylation and activates the downstream signaling pathway by promoting the interaction between EGFR molecules.

29 days ago

Journal

EGFR (Epidermal growth factor receptor) • TNFA (Tumor Necrosis Factor-Alpha) • VIM (Vimentin)

EGFR mutation • EGFR expression • EGFR wild-type • VIM expression

30d

The G-Protein-Coupled Estrogen Receptor Agonist G-1 Mediates Antitumor Effects by Activating Apoptosis Pathways and Regulating Migration and Invasion in Cervical Cancer Cells. (PubMed, Cancers (Basel))

GPER is a promising prognostic marker due to its ability to activate apoptosis and inhibit proliferation without promoting migration/invasion in CC cells. G-1 could potentially be a tool in the treatment of this neoplasia.

30 days ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • DKK1 (dickkopf WNT signaling pathway inhibitor 1) • TNFRSF9 (TNF Receptor Superfamily Member 9) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • VIM (Vimentin) • FOSL1 (FOS Like 1) • IL1B (Interleukin 1, beta) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)

DKK1 overexpression • VIM expression

A polysaccharide with a triple helix structure from Agaricus bisporus: Characterization and anti-colon cancer activity. (PubMed, Int J Biol Macromol)

Besides, WAAP-2 could inhibit the migration and invasion of colorectal cancer cells by inducing E-cadherin expression and inhibiting Vimentin expression to affect epithelial mesenchymal transition. This paper is of importance for the application of WAAP-2, a triple-helical structural polysaccharide from Agaricus bisporus, to low-toxicity anti-colon cancer drugs.

1 month ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • VIM (Vimentin)

BCL2 expression • CDH1 expression • BAX expression • VIM expression

Expression changes of miRNAs and EMT-related genes in human mesothelial cells induced by long-term exposure to asbestos (PubMed, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)

Compared with the control group, the expression levels of Vimentin, Twist and E-cadherin genes in chrysotile group were increased, while the expression levels of hsa-miR-34b-5p, hsa-miR-34c-5p and hsa-miR-28-5p were decreased (P<0.05) . Long-term exposure to chrysotile and crocidolite could cause Met-5A cells to produce miRNAs and EMT-related gene expression changes similar to mesothelioma cells.

1 month ago

Journal

CDH1 (Cadherin 1) • MIR155 (MicroRNA 155) • VIM (Vimentin) • MIR34B (MicroRNA 34b)

CDH1 expression • miR-155 expression • VIM expression

3D Scaffold-Based Culture System Enhances Preclinical Evaluation of Natural Killer Cell Therapy in A549 Lung Cancer Cells. (PubMed, ACS Appl Bio Mater)

Thus, it represents a valuable tool for investigating drug resistance mechanisms and assessing the efficacy of immune cell-based therapies. By bridging the gap between in vitro and in vivo investigations, this model effectively translates potential treatments into animal models and facilitates rigorous preclinical evaluations.

1 month ago

Preclinical • Journal • IO biomarker

VIM (Vimentin) • CDH2 (Cadherin 2)

VIM expression

Cisplatin‑resistant germ cell tumor models: An exploration of the epithelial‑mesenchymal transition regulator SLUG. (PubMed, Mol Med Rep)

Consistent with this finding, the NTERA‑2R mouse model demonstrated a significant upregulation in the expression levels of VIM and SLUG. In conclusion, the present findings suggested that SLUG may serve a crucial role in connecting EMT with the development of cisplatin resistance, and targeting SLUG may be a putative therapeutic strategy to mitigate cisplatin resistance.

1 month ago

Preclinical • Journal

FN1 (Fibronectin 1) • VIM (Vimentin) • TGFB1 (Transforming Growth Factor Beta 1) • SNAI2 (Snail Family Transcriptional Repressor 2)

VIM expression

cisplatin

miR-6884-5p inhibits proliferation and epithelial-mesenchymal transition in non-small cell lung cancer cells. (PubMed, Heliyon)

Moreover, miR-6884-5p effectively suppressed transforming growth factor β1-induced epithelial-mesenchymal transition, as evidenced by the restored expression of E-cadherin (p < 0.01), N-cadherin (p < 0.01) and Vimentin (p < 0.05), leading to the inhibition of migration and invasion in NSCLC cell lines. Our findings demonstrate that miR-6884-5p can inhibit NSCLC cell proliferation, migration, and invasion, suggesting its potential as a therapeutic target for NSCLC treatment.

1 month ago

Journal • IO biomarker

CDH1 (Cadherin 1) • BAX (BCL2-associated X protein) • VIM (Vimentin) • TGFB1 (Transforming Growth Factor Beta 1) • CDH2 (Cadherin 2)

CDH1 expression • VIM expression

Evaluation of epithelial-to-mesenchymal transition and Ki-67 index in aggressive papillary thyroid cancer. (PubMed, Braz J Otorhinolaryngol)

Patients that died from PTC had a significantly higher Ki-67 labelling index compared to patients with indolent disease (cutoff of 11%). Ki-67 may have a role as a prognostic marker and could be considered for routine use in PTC.

1 month ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDH1 (Cadherin 1) • VIM (Vimentin) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)

CDH1 expression • VIM expression

HIF-1α knockdown suppresses breast cancer metastasis via epithelial mesenchymal transition Abrogation. (PubMed, Heliyon)

The findings of this study demonstrate that HIF-1α knockdown effectively inhibits lung metastasis of 4T1 cells both in vitro and in vivo by suppressing EMT. These results underscore a promising new approach for managing breast cancer metastasis.

1 month ago

Journal

HIF1A (Hypoxia inducible factor 1, alpha subunit) • CDH1 (Cadherin 1) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9)

CDH1 expression • HIF1A expression • VIM expression

Cancer epithelial cells participate in the self-organization of lung tumor spheroids. A morphological approach. (PubMed, Cells Tissues Organs)

The results presented here indicate the participation of both epithelial and stromal cells in the control of spheroid self-organization. The experimental model proposed here, although preliminary, is useful for the study of some aspects related to tumor progression in lung cancer.

1 month ago

Journal

CDH1 (Cadherin 1) • CDH2 (Cadherin 2)

CDH1 expression • VIM expression