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DRUG CLASS:

VEGFR-3 inhibitor

21d
Targeting GPR34 in damage-associated macrophages enhances anti-tumor immunity and the efficacy of Surufatinib in pancreatic cancer. (PubMed, Signal Transduct Target Ther)
Combining a GPR34 antagonist with chemotherapy and surufatinib significantly enhanced anti-tumor responses in preclinical models. These findings identify GPR34 as a promising immune therapeutic target.
Journal
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CD8 (cluster of differentiation 8) • CSF1R (Colony stimulating factor 1 receptor)
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Sulanda (surufatinib)
25d
New trial
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Sulanda (surufatinib)
25d
A Study to Evaluate the Efficacy and Safety of Cadonilimab Plus Famitinib in Combination With Chemotherapy for Advanced Ovarian Cancer (ChiCTR2600117773)
P2, N=66, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of
New P2 trial • IO biomarker
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PD-L1 (Programmed death ligand 1) • CA 19-9 (Cancer antigen 19-9)
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carboplatin • paclitaxel • Kaitanni (cadonilimab) • famitinib (SHR 1020)
1m
New trial
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SSTR (Somatostatin Receptor) • SSTR2 (Somatostatin Receptor 2)
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Sulanda (surufatinib)
1m
New P2 trial
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retlirafusp alfa (SHR-1701) • famitinib (SHR 1020)
2ms
New P2/3 trial
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Loqtorzi (toripalimab-tpzi) • capecitabine • oxaliplatin • Sulanda (surufatinib)
2ms
New P2 trial
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Loqtorzi (toripalimab-tpzi) • oxaliplatin • irinotecan • Sulanda (surufatinib)
2ms
New trial
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PD-L1 (Programmed death ligand 1)
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AiRuiKa (camrelizumab) • famitinib (SHR 1020)
2ms
Pamiparib Plus Surufatinib in Patients With Platinum-resistant Ovarian Cancer (clinicaltrials.gov)
P1/2, N=29, Completed, Sun Yat-sen University | Recruiting --> Completed | Trial completion date: Aug 2025 --> Jan 2026
Trial completion • Trial completion date • Platinum resistant
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Partruvix (pamiparib) • Sulanda (surufatinib)
3ms
New P3 trial
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gemcitabine • capecitabine • albumin-bound paclitaxel • Sulanda (surufatinib)
3ms
HMPL-012-SPRING-P105: Efficacy and Safety of Surufatinib Combined With Gemcitabine and Albumin-bound Paclitaxel in the Peri-operative Treatment of Pancreatic Cancer (clinicaltrials.gov)
P2, N=29, Active, not recruiting, Tianjin Medical University Cancer Institute and Hospital | Recruiting --> Active, not recruiting
Enrollment closed
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gemcitabine • albumin-bound paclitaxel • Sulanda (surufatinib)
3ms
New P3 trial
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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ER positive • HR positive • HER-2 negative • HER-2 expression • HER-2 underexpression • PGR positive
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trastuzumab rezetecan (SHR-A1811) • famitinib (SHR 1020)