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    BIOMARKER:

    VEGFC elevation

    i
    Other names: VEGFC, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor-Related Protein, VRP, Flt4-L, VEGF-C, FLT4 Ligand DHM, Flt4 Ligand, LMPH1D, LMPHM4
    Entrez ID:
    7424
    Related biomarkers:
    Expression
    Others
    1year
    CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway. (PubMed, Cell Cycle)
    Mechanistically, circHGS functions as a sponge of miR-513a-5p to elevate VEGFC expression and activate the AKT/mTOR signaling pathway, ultimately promoting BCa progression. Our findings indicated that circHGS promotes BCa progression via the miR-513a-5p/VEGFC/AKT/mTOR pathway and can be a promising therapeutic target of BCa.
    Journal
    |
    VEGFC (Vascular Endothelial Growth Factor C) • MIR513A1 (MicroRNA 513a-1)
    |
    VEGFC elevation
    1year
    Identifying a surrogate biomarker for neuropilin-2 axis in serum of prostate cancer patients (AACR 2023)
    Our results indicated that plasma VEGF-C alone is not a prognostic indicator for prostate cancer. Since our studies using cell culture and animal models of prostate cancer have indicated the role of VEGF-C and the NRP2 axis in promoting metastasis and therapy resistance in prostate cancer, it would be useful to determine both the VEGF-C and NRP2 levels in the plasma of the same patients and study whether their level together would predict the outcome of medical therapy. Our ongoing experiments to determine plasma NRP2 levels in this patient cohort should be able to test this hypothesis.
    Clinical
    |
    VEGFC (Vascular Endothelial Growth Factor C)
    |
    VEGFC elevation
    1year
    Diagnostic and prognostic value of plasma cell-free DNA combined with VEGF-C in laryngeal squamous cell carcinoma. (PubMed, Mol Cell Probes)
    Indicators such as plasma cfDNA and VEGF-C may be used to diagnose and monitor LSCC for its noninvasiveness and rapid accessibility.
    Journal
    |
    VEGFC (Vascular Endothelial Growth Factor C)
    |
    VEGFC elevation
    over1year
    Risk Factors for Lymph Node Metastasis in Early Gastric Carcinoma: Clinicopathological Characteristics, Protein Expressions, Epstein-Barr Virus and Microsatellite Instability (USCAP 2023)
    LNM was confirmed in 9% of EGC. LNM was more likely to occur independently in Lauren diffuse/mixed type, stromal reaction, SM2 invasion, lymphatic invasion and high expressions of VEGF-C and SMAD2/3. These can be adopted as ancillary indicators for follow-up of EGC patients who underwent endoscopic resection without lymph node dissection.
    Clinical • Microsatellite instability
    |
    HER-2 (Human epidermal growth factor receptor 2) • MET (MET proto-oncogene, receptor tyrosine kinase) • MSI (Microsatellite instability) • CDH1 (Cadherin 1) • VEGFD (Vascular Endothelial Growth Factor D) • VEGFC (Vascular Endothelial Growth Factor C) • TGFB1 (Transforming Growth Factor Beta 1) • SMAD2 (SMAD Family Member 2)
    |
    VEGFA expression • VEGFC elevation
    2years
    Co-expression of VEGF-C and survivin predicts poor prognosis in esophageal squamous cell carcinoma. (PubMed, Transl Cancer Res)
    Co-expression of VEGF-C and survivin was predictive of poor prognosis in ESCC. Combined detection of VEGF-C and survivin could represent a feasible and effective marker to predict the prognosis and survival of ESCC patients.
    Journal
    |
    BIRC5 (Baculoviral IAP repeat containing 5) • FLT4 (Fms-related tyrosine kinase 4) • VEGFC (Vascular Endothelial Growth Factor C)
    |
    BIRC5 expression • BIRC5 overexpression • VEGFA expression • VEGFC elevation