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    BIOMARKER:

    VEGFB expression

    i
    Other names: VEGFB, Vascular Endothelial Growth Factor B, VEGF-Related Factor, VRF, VEGF-B, VEGFL
    Entrez ID:
    7423
    Related biomarkers:
    Expression
    Others
    over1year
    Multi-omics analysis of the biological function of the VEGF family in colon adenocarcinoma. (PubMed, Funct Integr Genomics)
    In addition, our research suggests that VEGFB not only promotes angiogenesis but is also involved in the tumor microenvironment and immune regulation. The SHNG17-miR-375-VEGFB regulatory axis provides a potential therapeutic target for COAD, highlighting VEGFB's role in immune activation during anti-angiogenic therapy and potential reversal of drug resistance.
    Journal
    |
    VEGFA (Vascular endothelial growth factor A) • VEGFB (Vascular Endothelial Growth Factor B) • MIR375 (MicroRNA 375)
    |
    VEGFB expression
    almost2years
    Chondroitin polymerizing factor promotes development and progression of colorectal cancer via facilitating transcription of VEGFB. (PubMed, J Cell Mol Med)
    Functionally, suppressing VEGFB expression successfully mitigated the oncogenic effects induced by CHPF overexpression. Collectively, these findings suggest that CHPF may act as a tumour promoter in CRC, operating in a VEGFB-dependent manner and could be a potential target for therapeutic interventions in CRC treatment.
    Journal
    |
    VEGFB (Vascular Endothelial Growth Factor B) • CHPF (Chondroitin Polymerizing Factor) • E2F1 (E2F transcription factor 1)
    |
    VEGFB expression
    2years
    Expression of PTGS2 along with genes regulating VEGF signalling pathway and association with high-risk factors in locally advanced oral squamous cell carcinoma. (PubMed, Cancer Med)
    PTGS2 and VEGF signalling genes are upregulated in OSCC, which has a profound impact on clinical outcomes.
    Journal • Metastases
    |
    KDR (Kinase insert domain receptor) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • VEGFB (Vascular Endothelial Growth Factor B) • CXCR1 (Chemokine (C-X-C motif) receptor 1) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
    |
    PTGS2 expression • VEGFB expression
    over2years
    Comprehensive analysis of the oncogenic roles of vascular endothelial growth factors and their receptors in stomach adenocarcinoma. (PubMed, Heliyon)
    The expression of VEGFs and VEGFRs was remarkably associated with immune cell infiltration and immune checkpoint expression in STAD patients. Our study systematically explored the transcriptome profiles and distinct prognostic values of VEGFs and their receptors in STAD and contributed to a better understanding of the oncogenic roles of VEGF/VEGFR members in STAD.
    Journal
    |
    KDR (Kinase insert domain receptor) • FLT1 (Fms-related tyrosine kinase 1) • FLT4 (Fms-related tyrosine kinase 4) • VEGFD (Vascular Endothelial Growth Factor D) • VEGFB (Vascular Endothelial Growth Factor B) • VEGFC (Vascular Endothelial Growth Factor C) • NRP1 (Neuropilin 1)
    |
    VEGFB expression
    almost3years
    LncRNA DANCR Enhances Angiogenesis to Promote Melanoma Progression Via Sponging miR-5194. (PubMed, J Cancer)
    Mechanistic analysis revealed that DANCR upregulating VEGFB through sponging miR-5194, which negatively regulated VEGFB expression and secretion. We demonstrated a novel oncogenic role DANCR played in melanoma and suggested a new avenue for melanoma therapy by targeting the DANCR/miR-5194/VEGFB signaling.
    Journal
    |
    VEGFB (Vascular Endothelial Growth Factor B) • DANCR (Differentiation Antagonizing Non-Protein Coding RNA)
    |
    VEGFB expression
    3years
    LncRNA NEAT2 regulates oral squamous cell carcinoma progression via VEGFB and TGF-β/Smad3 pathway. (PubMed, Oral Dis)
    NEAT2 downregulation inhibited cell proliferation and EMT through VEGFB and TGF-β/Smad3 pathway in vitro, disclosing a new regulatory mechanism in OSCC. In addition, downregulation of NEAT2 could inhibit the tumor growth and metastasis.
    Journal
    |
    MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • VEGFB (Vascular Endothelial Growth Factor B) • TGFB1 (Transforming Growth Factor Beta 1) • SMAD3 (SMAD Family Member 3)
    |
    VEGFB expression
    over3years
    Inflammation- and Metastasis-Related Proteins Expression Changes in Early Stages in Tumor and Non-Tumor Adjacent Tissues of Colorectal Cancer Samples. (PubMed, Cancers (Basel))
    Furthermore, non-tumor adjacent tissue presented an increase of the inflammatory status that could be the basis for future tumor progression. In conclusion, these proteins could be useful as biomarkers of diagnosis for CRC at early stages.
    Journal
    |
    VEGFB (Vascular Endothelial Growth Factor B) • VIM (Vimentin)
    |
    VIM expression • VEGFB expression
    over3years
    Single-cell RNA sequencing reveals differential expression of EGFL7 and VEGF in giant-cell tumor of bone and osteosarcoma. (PubMed, Exp Biol Med (Maywood))
    TNFSF11 (or RANKL) shows high expression in CAFs and osteoblastic OS cells in OS, and osteoblasts in GCTB. This study investigates pro-angiogenic genes in GCTB and OS and suggests that these genes and their expression patterns are cell-type specific and could provide potential prognostic biomarkers and cell type target treatment for GCTB and OS.
    Journal
    |
    VEGFA (Vascular endothelial growth factor A) • VEGFD (Vascular Endothelial Growth Factor D) • VEGFB (Vascular Endothelial Growth Factor B) • VEGFC (Vascular Endothelial Growth Factor C) • TNFSF11 (TNF Superfamily Member 11)
    |
    VEGFB expression