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    BIOMARKER:

    VCAN mutation

    i
    Other names: VCAN, Versican, Versican core protein, Chondroitin sulfate proteoglycan core protein 2, Chondroitin sulfate proteoglycan 2, Glial hyaluronate-binding protein, GHAP, Large fibroblast proteoglycan, PG-M, CSPG2, WGN1, ERVR, Versican proteoglycan
    Entrez ID:
    1462
    over1year
    Proteogenomic Characterization of Early Intrahepatic Recurrence after Curative-Intent Treatment of Colorectal Liver Metastases. (PubMed, J Proteome Res)
    Calponin-2, versican core protein, glutathione peroxidase 3, fibulin-5, and amyloid-β precursor protein were upregulated more than 2-fold in early recurrence. Exploratory analysis of these proteogenomic biomarkers suggests that SMAD4, calponin-2, and glutathione peroxidase 3 may have the potential to predict early recurrence, enabling improved prognostication and precision oncology in CRLM.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • SMAD4 (SMAD family member 4) • APP (Amyloid Beta Precursor Protein) • VCAN (Versican)
    |
    TP53 mutation • KRAS mutation • VCAN mutation
    |
    TruSight Oncology 500 Assay
    over2years
    Versican core protein aids in the diagnosis and grading of breast phyllodes tumor. (PubMed, Ann Diagn Pathol)
    To the best of our knowledge, our results are the first in the literature to reveal that VCAN is useful for diagnosing and grading PTs. The expression level of VCAN appeared to be negatively associated with PT categories, suggesting that dysregulation of VCAN may be involved in the tumor progression of PTs.
    Journal
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    CD34 (CD34 molecule) • VCAN (Versican)
    |
    VCAN mutation