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    BIOMARKER:

    VCAM1 overexpression

    i
    Other names: VCAM1, Vascular Cell Adhesion Molecule 1, Vascular Cell Adhesion Protein 1, CD106 Antigen, INCAM-100, CD106, V-CAM 1, VCAM-1, VCAM1
    Entrez ID:
    7412
    1year
    The isolation of VCAM-1+ endothelial cell-derived extracellular vesicles using microfluidics. (PubMed, Extracell Vesicles Circ Nucl Acids)
    This study presents a novel approach using the EVHB-Chip, coated with anti-VCAM-1 antibodies and digital droplet PCR for the study of VCAM-1+ EC-EVs. Isolation of VCAM-1+ EC-EV from heterogeneous sources such as conditioned cell culture media holds promise for subsequent detailed characterization, and may facilitate the study of VCAM-1+ EC-EVs in cardiovascular and metabolic diseases, for disease monitoring and therapeutic insights.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • ICAM1 (Intercellular adhesion molecule 1) • CD9 (CD9 Molecule) • TERC (Telomerase RNA Component) • VCAM1 (Vascular Cell Adhesion Molecule 1)
    |
    VCAM1 overexpression
    almost5years
    High VCAM-1 Predicts Poor Prognosis and is Associated with Chemotherapy Resistance in Nasopharyngeal Carcinoma. (PubMed, Onco Targets Ther)
    The sensitivity rates of NPC to eight chemotherapy drugs were different; carboplatin and docetaxel showed the highest chemotherapy sensitivity and resistance rates, respectively. The resistance rates to paclitaxel were different between the patients with high VCAM-1 expression and those with low VCAM-1 expression...VCAM-1 could be a prognostic marker of NPC patients. The detection of VCAM-1 expression in NPC may be valuable for chemotherapy drug evaluation and management of patients with NPC in the clinic.
    Journal
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    VCAM1 (Vascular Cell Adhesion Molecule 1)
    |
    VCAM1 overexpression
    |
    carboplatin • paclitaxel • docetaxel