^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    VAX014 intravesicular

    i
    Other names: VAX014 intravesicular, VAX 014 intravesicular
    Associations

    News

    Trials
    Company:
    Vaxiion Therap
    Drug class:
    α3β1 integrin inhibitor, α5β1 integrin inhibitor
    Related drugs:
    Associations

    News

    Trials
    over3years
    Intravesical VAX014 Synergizes with PD-L1 Blockade to Enhance Local and Systemic Control of Bladder Cancer. (PubMed, Cancer Immunol Res)
    Finally, VAX014's target integrins α3β1 and α5β1 were overexpressed in tumor biopsies from advanced stage bladder cancer patients, as well as in both the MB49 and MBT-2 orthotopic mouse models of bladder cancer. These collective findings provide rationale for clinical investigation of VAX014 and systemic PD-1/PD-L1 blockade in advanced stage bladder cancer.
    Journal
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule)
    |
    VAX014 intravesicular