Uterine Cancer

We present a unique case of primary pelvic extraskeletal Ewing sarcoma in a previously healthy young woman with localized invasion into the uterus, vagina, and bladder. Given the rarity of this disease, paucity of data, and potential for misdiagnosis, clinicians must maintain high suspicion for pelvic extraskeletal Ewing sarcoma.

P=N/A, N=5000, Recruiting, Dana-Farber Cancer Institute

Based on the anatomopathological, histochemical, and immunohistochemical findings, uterine leiomyoma and cystic endometrial hyperplasia were diagnosed. This case highlights the importance of diagnosing neoplasms and other conditions in captive elephants to better understand the diseases affecting these animals.

Combined detection of ATRX expression and ALT activation status can effectively assist in the differential diagnosis of uLMS from its mimickers. In addition, the presence of ATRX loss and/or ALT activation in STUMP and uLM suggests a malignant potential and seems to warrant close clinical follow-up and individualized diagnosis and treatment decisions.

Our results highlight that these lincRNAs can serve as new biomarkers for the prognostic prediction of USC. In particular, ENSG00000204277 may be used as a therapeutic target for USC.

Metastasis of breast ILCs to the uterine cervix poses a significant diagnostic challenge. A high index of clinical suspicion and detailed clinical history are essential for accurate diagnosis.

Invasive lobular carcinoma (ILC) demonstrates a documented predilection for unusual metastatic patterns including the female genital tract, while tamoxifen-associated endometrial pathology may complicate diagnosis in breast cancer survivors...Endometrial sampling should be considered with a low threshold in breast cancer survivors with abnormal uterine bleeding, and breast imaging is warranted when discohesive cells are encountered without a known breast primary. These proportions describe the published case literature rather than population-based prevalence; because the evidence is limited to case reports and small series, they should not be read as the true frequency of uterine involvement among women with breast cancer.

Next-generation sequencing and fluorescence in situ hybridization confirmed the EWSR1 (exon 15)::CREM (exon 6) fusion in both cases. These uterine neoplasms broaden the spectrum of malignant epithelioid neoplasms and should be included in the differential diagnosis of epithelioid neoplasms involving the female reproductive system.

Our ML approach accurately predicted MSI status in colorectal and uterine cancers using multiomics data derived from NGS, without relying on direct microsatellite sequencing. The ability to identify MSI-high tumors among indeterminate cases demonstrates potential to improve diagnostic precision and ensures timely access to immunotherapy for patients with MSI-high disease.

P1/2, N=200, Not yet recruiting, University of Nebraska

P3, N=360, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended

These immunophenotypes are not specific because other epithelial and non-epithelial uterine tumors may exhibit overlapping features. Therefore, a comprehensive pathological understanding of UEC is essential for avoiding diagnostic pitfalls and improving diagnostic accuracy.