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    GENE:

    USP42 (Ubiquitin Specific Peptidase 42)

    i
    Other names: USP42, Ubiquitin Specific Peptidase 42, Ubiquitin-Specific-Processing Protease 42, Ubiquitin Carboxyl-Terminal Hydrolase 42, Ubiquitin Specific Protease 42, Deubiquitinating Enzyme 42, Ubiquitin Thioesterase 42, FLJ12697, Ubiquitin Thiolesterase 42
    3ms
    Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma. (PubMed, Int J Mol Sci)
    siRNA-mediated USP42 downregulation in Nthy-Ori 3-1 cells resulted in reduced cell viability, morphological changes, and modifications in cell cycle-related proteins. Our results suggest a pivotal role of USP42 mutation in thyroid cell biology, and this finding indicates that USP42 may serve as a new putative target in FNMTC.
    Journal
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    CCND1 (Cyclin D1) • CASP3 (Caspase 3) • USP42 (Ubiquitin Specific Peptidase 42) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • USP13 (Ubiquitin Specific Peptidase 13)
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    TP53 mutation • CCND1 expression • TP53 expression • USP42 mutation
    11ms
    MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24. (PubMed, Life Sci)
    miR-21-5p promotes deterioration and sorafenib resistance in hepatocellular carcinoma by upregulating autophagy levels. Knockdown of miR-21-5p inhibits the development of sorafenib-resistant tumors by USP24-mediated SIRT7 ubiquitination.
    Journal
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    CDH1 (Cadherin 1) • MIR21 (MicroRNA 21) • VIM (Vimentin) • CDH2 (Cadherin 2) • USP42 (Ubiquitin Specific Peptidase 42) • BECN1 (Beclin 1) • SIRT7 (Sirtuin 7)
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    VIM expression • miR-21 overexpression
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    sorafenib