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    BIOMARKER:

    USP42 mutation

    i
    Other names: USP42, Ubiquitin Specific Peptidase 42, Ubiquitin-Specific-Processing Protease 42, Ubiquitin Carboxyl-Terminal Hydrolase 42, Ubiquitin Specific Protease 42, Deubiquitinating Enzyme 42, Ubiquitin Thioesterase 42, FLJ12697, Ubiquitin Thiolesterase 42
    Entrez ID:
    84132
    3ms
    Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma. (PubMed, Int J Mol Sci)
    siRNA-mediated USP42 downregulation in Nthy-Ori 3-1 cells resulted in reduced cell viability, morphological changes, and modifications in cell cycle-related proteins. Our results suggest a pivotal role of USP42 mutation in thyroid cell biology, and this finding indicates that USP42 may serve as a new putative target in FNMTC.
    Journal
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    CCND1 (Cyclin D1) • CASP3 (Caspase 3) • USP42 (Ubiquitin Specific Peptidase 42) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • USP13 (Ubiquitin Specific Peptidase 13)
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    TP53 mutation • CCND1 expression • TP53 expression • USP42 mutation