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    GENE:

    USP2-AS1 (USP2 Antisense RNA 1)

    i
    Other names: USP2-AS1, USP2 Antisense RNA 1, USP2 Antisense RNA 1 (Head To Head), THY1-AS1, GlycoLINC, GLINC, NONHSAG009822.2, HSALNG0087648, USP2-AS1
    Associations

    News

    Trials
    9ms
    LncRNA USP2-AS1 Facilitates Colorectal Cancer Development Through The PHLDA2/PI3K/AKT Axis. (PubMed, Exp Cell Res)
    In conclusion, USP2-AS1 could upregulate PHLDA2 expression by recruiting IGF2BP2 and competitively binding miR-134-5p, thus activating the PI3K/AKT signalling pathway and facilitating CRC malignant progression. Our results prove that USP2-AS1 is a prospective target of CRC.
    Journal
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    IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • USP2-AS1 (USP2 Antisense RNA 1) • MIR134 (MicroRNA 134)
    1year
    Novel pyroptosis-immune-related lncRNA signature exhibits a distinct immune cell infiltration landscape in breast cancer. (PubMed, Front Immunol)
    The six-lncRNA pyroptosis-immune signature effectively predicted BC prognosis and highlighted distinct immune cell infiltration patterns. This holds promise for evaluating immunotherapy responses and guiding therapeutic target identification in BC.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-1 (Programmed cell death 1) • CD276 (CD276 Molecule) • KIR3DL2 (Killer Cell Immunoglobulin Like Receptor Three Ig Domains And Long Cytoplasmic Tail 2) • KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) • CD40LG (CD40 ligand) • KIR2DS4 (Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 4) • MAPT (Microtubule Associated Protein Tau) • TDO2 (Tryptophan 2,3-Dioxygenase) • USP2-AS1 (USP2 Antisense RNA 1)
    2years
    LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway. (PubMed, RNA Biol)
    Additionally, USP2-induced Wnt/β-catenin signalling pathway activation via deubiquitination of β-catenin protein. In summary, our study proved that lncRNA USP2-AS1 facilitates the osteogenic differentiation of HBMSCs by targeting KDM3A/ETS1/USP2 axis to activate the Wnt/β-catenin signalling pathway.
    Journal
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    ETS1 (ETS Proto-Oncogene 1) • KDM3A (Lysine Demethylase 3A) • USP2-AS1 (USP2 Antisense RNA 1)
    almost3years
    Identification and Characterization of an Ageing-Associated 13-lncRNA Signature That Predicts Prognosis and Immunotherapy in Hepatocellular Carcinoma. (PubMed, J Oncol)
    Cell senescence is an essential factor in HCC onset and progression. We identified 13 senescence-related lncRNAs as HCC prognostic markers, which can help understand their function in the onset and progression of HCC and guide clinical diagnosis and treatment.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • MIR99A (MicroRNA 99a) • LINC01116 (Long Intergenic Non-Protein Coding RNA 1116) • SLC25A3 (Solute Carrier Family 25 Member 3) • USP2-AS1 (USP2 Antisense RNA 1)
    3years
    A novel cuproptosis-related prognostic 2-lncRNAs signature in breast cancer. (PubMed, Front Pharmacol)
    qPCR results showed that two model lncRNAs (USP2-AS1, NIFK-AS1) and three Cuproptosis genes (FDX1, PDHA1, DLAT) expressed differently between 10 pairs of breast cancer tissue samples and adjacent samples. The current study reveals that cuproptosis-related prognostic 2-lncRNAs signature (BCCuS) may be useful in predicting the prognosis, biological characteristics, and appropriate treatment of breast cancer patients.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • DLAT (Dihydrolipoamide S-Acetyltransferase) • FDX1 (Ferredoxin 1) • PDHA1 (Pyruvate Dehydrogenase E1 Subunit Alpha 1) • USP2-AS1 (USP2 Antisense RNA 1)
    over3years
    Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression. (PubMed, Cells)
    Moreover, the knockdown of DCAF13 restored the elevated cell proliferation and growth levels achieved by USP2-AS1 overexpression. Altogether, we found that lncRNA USP2-AS1 functions as a HIF1α-regulated oncogenic lncRNA and promotes HNSCC cell proliferation and growth by interacting and modulating the activity of DCAF13.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • DDB1 (Damage Specific DNA Binding Protein 1) • USP2-AS1 (USP2 Antisense RNA 1)