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    BIOMARKER:

    USP18 overexpression

    i
    Other names: USP18, Ubiquitin Specific Peptidase 18, Ubl Carboxyl-Terminal Hydrolase 18, ISG15-Specific-Processing Protease, Ubiquitin Specific Protease 18, 43 KDa ISG15-Specific Protease, Ubl Thioesterase 18, ISG43, Ubl Thiolesterase 18, PTORCH2, HUBP43, UBP43
    Entrez ID:
    11274
    over1year
    USP18 promotes the proliferation, invasion, and migration of head and neck squamous cell carcinoma by deubiquitinating PLK1. (PubMed, Exp Cell Res)
    Subsequently, we validated that USP18 modulated PLK1 to activate the mTORC1 pathway, thereby facilitating HNSC cell proliferation, invasion, and migration. In conclusion, our findings demonstrate that elevated expression of USP18 in HNSC cells promotes tumorigenesis by regulating the PLK1-mTORC1 pathway.
    Journal
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    PLK1 (Polo Like Kinase 1) • USP18 (Ubiquitin Specific Peptidase 18) • USP1 (Ubiquitin Specific Peptidase 1)
    |
    USP18 overexpression
    over1year
    USP18 Is Associated with PD-L1 Antitumor Immunity and Improved Prognosis in Colorectal Cancer. (PubMed, Biomolecules)
    In summary, USP18 shows great promise for research and clinical application as a potential target for CRC immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • USP18 (Ubiquitin Specific Peptidase 18)
    |
    USP18 overexpression
    over3years
    USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway. (PubMed, Acta Biochim Pol)
    Inhibition of AKT attenuated the decrease in cell apoptosis induced by USP18 overexpression and increased cell viability and migration. In conclusion, USP18 promoted the proliferation and migration of ovarian cancer cells by activating AKT/mTOR signaling.
    Journal
    |
    USP18 (Ubiquitin Specific Peptidase 18)
    |
    USP18 overexpression
    almost4years
    USP18 reduces paclitaxol sensitivity of triple-negative breast cancer via autophagy. (PubMed, Biochem Biophys Res Commun)
    In this study, differential expressed genes (DEGs) between TNBC cells and paclitaxol-resistant (taxol-R) TNBC cells were screened by bioinformatics analysis...The autophagy inhibitor leupeptin could effectively reverse the effect of USP18 on paclitaxol resistance phenotype. These findings suggested that USP18 may be a promising target for overcoming paclitaxol resistance in TNBC.
    Journal
    |
    USP18 (Ubiquitin Specific Peptidase 18)
    |
    USP18 overexpression
    |
    paclitaxel