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    GENE:

    UQCRQ (Ubiquinol-Cytochrome C Reductase Complex III Subunit VII)

    i
    Other names: UQCRQ, Ubiquinol-Cytochrome C Reductase Complex III Subunit VII, Complex III Subunit 8, UQCR7, QP-C, QCR8, Ubiquinol-Cytochrome C Reductase Complex Ubiquinone-Binding Protein QP-C, Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII, 9.5kDa, Ubiquinol-Cytochrome C Reductase Complex 9.5 KDa Protein, Cytochrome B-C1 Complex Subunit 8, Complex III Subunit VIII, Ubiquinol-Cytochrome C Reductase, Complex III Subunit VII, Low Molecular Mass Ubiquinone-Binding Protein (9.5kD), MC3DN4, QPC
    Associations

    News

    Trials
    2ms
    WTAP-mediated N6-methyladenosine modification of UQCRQ promotes mitochondrial ROS and inflammatory response in microglia after intracerebral hemorrhage. (PubMed, Biochem Biophys Res Commun)
    Further analysis demonstrated that insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) binds UQCRQ mRNA, enhancing its stability and protein expression, counteracting the effects of WTAP knockdown on cell viability, mitochondrial ROS, and inflammation. Our findings suggest that WTAP contributes to neuronal damage via UQCRQ in an m6A-IGF2BP1-dependent manner after OGD/H, indicating that targeting WTAP/m6A/IGF2BP1 downregulation could protect neuronal function after ICH.
    Journal
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    WT1 (WT1 Transcription Factor) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • UQCRQ (Ubiquinol-Cytochrome C Reductase Complex III Subunit VII) • WTAP (WT1 Associated Protein)