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    BIOMARKER:

    UHMK1 overexpression

    i
    Other names: UHMK1, U2AF Homology Motif Kinase 1, KIS, PAM COOH-Terminal Interactor Protein 2, Serine/Threonine-Protein Kinase Kist, U2AF Homology Motif (UHM) Kinase 1, P-CIP2, Kist, KIST, Kinase Interacting With Leukemia-Associated Gene (Stathmin), Kinase Interacting With Stathmin, KIS Protein Kinase
    Entrez ID:
    127933
    Associations

    News

    Trials
    almost4years
    UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling. (PubMed, Cell Death Dis)
    The complementary experiments for cell growth and oxaliplatin resistance indicated the interdependent relationship between UHMK1 and STAT3. Thus, these collective findings uncovered a new UHMK1/STAT3 positive feedback regulatory loop contributing to CRC development and chemoresistance.
    Journal
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    IL6 (Interleukin 6) • UHMK1 (U2AF Homology Motif Kinase 1)
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    UHMK1 overexpression
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    oxaliplatin