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    BIOMARKER:

    UGT1A1∗1

    i
    Other names: UGT1A1, UDP glucuronosyltransferase family 1 member A1, GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1
    Entrez ID:
    54658
    Related biomarkers:
    Mutation
    almost3years
    Sacituzumab Govitecan, a Trop-2-Directed Antibody-Drug Conjugate, for Patients with Epithelial Cancer: Final Safety and Efficacy Results from the Phase 1/2 IMMU-132-01 Basket Trial. (PubMed, Ann Oncol)
    SG demonstrated a toxicity profile consistent with previous published reports. Efficacy was seen in several cancer cohorts, which validates Trop-2 as a broad target in solid tumors.
    Clinical • P1/2 data • Clinical Trial,Phase I • Clinical Trial,Phase II • Journal • Pan tumor
    |
    TROP2 (Trophoblast Cell Surface Antigen 2) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
    |
    UGT1A1*28 • UGT1A1∗1
    |
    Trodelvy (sacituzumab govitecan-hziy)