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    GENE:

    UGP2 (UDP-Glucose Pyrophosphorylase 2)

    i
    Other names: UGP2, UDP-Glucose Pyrophosphorylase 2, UTP--Glucose-1-Phosphate Uridylyltransferase, SVUGP2, UGPP1, UGP1, UDP-Glucose Pyrophosphorylase 1, UDPGP, UTP--Glucose-1-Phosphate Uridylyltransferase 2, Uridyl Diphosphate Glucose Pyrophosphorylase-1, Uridyl Diphosphate Glucose Pyrophosphorylase 2, Testis Tissue Sperm-Binding Protein Li 58p, UTP-Glucose-1-Phosphate Uridyltransferase, UDP-Glucose Pyrophosphorylase, UDP-Glucose Diphosphorylase, UGPase 2, EIEE83, UDPGP2, PHC379, UGPase, DEE83, UGPP2, UDPG
    24d
    Role of UGP2 as a Biomarker in Colorectal Cancer: Implications for Tumor Progression, Diagnosis, and Prognosis. (PubMed, Curr Issues Mol Biol)
    Conversely, its overexpression yielded the opposite effects, confirming UGP2's role in constraining malignant phenotypes. Collectively, these findings establish UGP2 as a key CRC tumor suppressor whose downregulation drives malignant progression and predicts adverse clinical outcomes, suggesting its potential as a dual-purpose diagnostic and prognostic biomarker.
    Journal
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    UGP2 (UDP-Glucose Pyrophosphorylase 2)
    2ms
    High glucose enhances lung cancer cell aggressiveness: The impacts of GLUT1, UAP1, UGP2, and N-linked Glycosylation. (PubMed, Glycobiology)
    Our findings highlight the roles of GLUT1-UAP1-UGP2 axis and N-linked glycosylation in high glucose-induced progression of lung cancer cells. GLUT1, UAP1, and UGP2 may serve as prognostic markers and potential targets for future lung cancer treatments.
    Journal
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    CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • VIM (Vimentin) • XIAP (X-Linked Inhibitor Of Apoptosis) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SNAI2 (Snail Family Transcriptional Repressor 2) • UGP2 (UDP-Glucose Pyrophosphorylase 2) • SLC2A1 (Solute Carrier Family 2 Member 1)
    3ms
    UGP2 is a potential target for breast cancer, based on bioinformatics analysis and in vitro experiments. (PubMed, Sci Rep)
    Mechanistic analyses reveal UGP2's functional involvement in both tumor cell proliferation and stromal remodeling through cancer-associated fibroblast (CAF) interactions. The robust association between UGP2 overexpression and aggressive clinicopathological features positions it as both a promising prognostic biomarker and potential therapeutic target, particularly in TNBC management.
    Preclinical • Journal
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    UGP2 (UDP-Glucose Pyrophosphorylase 2)