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    DRUG:

    KRLS-017

    i
    Other names: KRLS-017, UD017, UD 017, UD-017
    Company:
    Kirilys, Ube Corp
    Drug class:
    CDK7 inhibitor
    Related drugs:
    2years
    Targeting CDK7 enhances the antitumor efficacy of enzalutamide in androgen receptor-positive triple-negative breast cancer (SABCS 2022)
    Our results suggest that enzalutamide synergizes with UD-017 by inhibiting c- MYC–mediated oncogenic activity. These in vitro data warrant future in vivo studies of the antitumor synergy of enzalutamide plus UD-017 in AR+ LAR TNBC models.
    Clinical
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • AR (Androgen receptor) • CDK7 (Cyclin Dependent Kinase 7)
    |
    AR positive • MYC overexpression • MYC expression • AR expression
    |
    Xtandi (enzalutamide capsule) • KRLS-017