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    GENE:

    UBE2N (Ubiquitin Conjugating Enzyme E2 N)

    i
    Other names: UBE2N, Ubiquitin Conjugating Enzyme E2 N, Ubiquitin-Conjugating Enzyme E2N (Homologous To Yeast UBC13), Ubiquitin-Conjugating Enzyme E2N (UBC13 Homolog, Yeast), Ubiquitin-Conjugating Enzyme E2 N, E2 Ubiquitin-Conjugating Enzyme N, Ubiquitin Carrier Protein N, Ubiquitin-Protein Ligase N, UbcH-Ben, UbcH13, UBC13, Bendless-Like Ubiquitin Conjugating Enzyme, Bendless-Like Ubiquitin-Conjugating Enzyme, Epididymis Secretory Protein Li 71, Ubiquitin-Conjugating Enzyme E2N, Ubiquitin Conjugating Enzyme E2N, Yeast UBC13 Homolog, UBCHBEN; UBC13, HEL-S-71, MGC8489, UBE2N, Ubc13, BLU
    Associations

    News

    Trials
    6ms
    UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma. (PubMed, Front Immunol)
    UBE2N may serve as a promising prognostic biomarker and therapeutic target for LUAD. Inhibition of UBE2N is expected to suppress LUAD progression and enhance therapeutic efficacy.
    Journal • IO biomarker
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    UBE2N (Ubiquitin Conjugating Enzyme E2 N)
    over1year
    TAF15 inhibits p53 nucleus translocation and promotes HCC cell 5-FU resistance via post-transcriptional regulation of UBE2N. (PubMed, J Physiol Biochem)
    This study explored the role played by UBE2N in development of 5-fluorouracil (5-FU) resistance in HCC cells...Collectively, our present study identified a novel mechanism by which TAF15/UBE2N regulates p53 distribution to increase 5-FU resistance. Our results also suggest potential therapeutic strategies for treating HCC.
    Journal
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    TAF15 (TATA-Box Binding Protein Associated Factor 15) • UBE2N (Ubiquitin Conjugating Enzyme E2 N)
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    TP53 mutation • TP53 wild-type • UBE2N expression
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    5-fluorouracil
    almost2years
    UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells. (PubMed, Biol Direct)
    XAV939 or Axin1 overexpression was co-treated with UBE2N overexpression to detect the involvement of the Wnt/β-catenin signaling and Axin1 in the UBE2N function...Wnt/β-catenin inhibition and Axin1 overexpression reversed the promoting viability and glycolysis function of UBE2N. UBE2N promoted Axin1 ubiquitination and decreased Axin1 protein level.
    Journal
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    AXIN1 (Axin 1) • UBE2N (Ubiquitin Conjugating Enzyme E2 N)
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    UBE2N expression
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    XAV-939
    almost3years
    SP1 transcriptionally regulates UBE2N expression to promote lung adenocarcinoma progression. (PubMed, Mol Biomed)
    Importantly, LUAD patients with concomitantly high expression of SP1 and UBE2N were significantly associated with poor clinical outcomes. In conclusion, our study demonstrated that the SP1-UBE2N signaling axis might play a key role in the malignant progression of LUAD, which provides new targets and strategies for the treatment of LUAD.
    Journal
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    SP1 (Sp1 Transcription Factor) • UBE2N (Ubiquitin Conjugating Enzyme E2 N)
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    UBE2N expression