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    GENE:

    UBE2C (Ubiquitin Conjugating Enzyme E2 C)

    i
    Other names: UBE2C, Ubiquitin Conjugating Enzyme E2 C, UBCH10
    Associations

    News

    Trials
    11d
    SUMOylation of UBE2C facilitates hepatocellular carcinoma proliferation and invasion via the MAPK pathway. (PubMed, Transl Cancer Res)
    Rescue experiments were performed with the MAPK inhibitor trametinib...We reveal a novel oncogenic axis in which MYBL2 and SUMOylation cooperatively increase UBE2C expression and stability, promoting HCC progression via MAPK pathway activation. Targeting the MYBL2/UBE2C/MAPK axis represents a potential therapeutic strategy for treating HCC.
    Journal
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    PLCG2 (Phospholipase C Gamma 2) • MYBL2 (MYB Proto-Oncogene Like 2) • PRKCB (Protein Kinase C Beta) • UBE2C (Ubiquitin Conjugating Enzyme E2 C) • UBE2I (Ubiquitin Conjugating Enzyme E2 I)
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    Mekinist (trametinib)
    20d
    Single-cell analysis identifies ATC-like cells driving progression in relapsed follicular thyroid carcinoma. (PubMed, Endocrinology)
    This reveals a previously unrecognized population of ATC-like cells in RFTC marked by high UBE2C expression. UBE2C contributes to FTC progression by enhancing proliferation and modulating key metabolic pathways, suggesting it as both a critical biomarker of aggressive disease and a potential therapeutic target.
    Journal
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    UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    24d
    Integrative Bioinformatics and Experimental Validation Establish CCNB1 as a Potential Biomarker for Diagnosis and Prognosis in Colorectal Cancer. (PubMed, Curr Issues Mol Biol)
    In vitro, CCNB1 knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated CCNB1 as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • CDCA3 (Cell Division Cycle Associated 3) • CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • MCM4 (Minichromosome Maintenance Complex Component 4) • CCNB1 (Cyclin B1) • CDK3 (Cyclin Dependent Kinase 3) • CEP55 (Centrosomal Protein 55) • CKS2 (CDC28 Protein Kinase Regulatory Subunit 2) • CRYAB (Crystallin Alpha B) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MMP3 (Matrix metallopeptidase 3) • TPM2 (Tropomyosin 2) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    1m
    Identification of a Cuproptosis-Related Molecular Signature for Predicting Biochemical Recurrence in Prostate Cancer. (PubMed, Comb Chem High Throughput Screen)
    This study initially identified two cuproptosis-related molecules based on the expression patterns of cuproptosis-related genes. In addition, we developed a new cuproptosisrelated molecular signature with great predictive performance for BCRFS and tumor immune environment using six DERRGs (including CALML5, MMP11, UBE2C, ANPEP, TMEM59L, COMP). These findings would be conducive to a deeper cognition of the potential mechanism of cuproptosis of PCa.
    Journal • IO biomarker
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    MMP11 (Matrix Metallopeptidase 11) • ANPEP (Alanyl Aminopeptidase, Membrane) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    1m
    A bird's eye view on potential molecular prognostic markers in retinoblastoma: insights for precision oncology. (PubMed, Ophthalmic Genet)
    The integration of AH liquid biopsy in RB management may aid prognosis prediction and optimize treatment strategies. However, further research is needed to validate the prognostic significance.
    Review • Journal
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    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • BIRC5 (Baculoviral IAP repeat containing 5) • AURKA (Aurora kinase A) • AURKB (Aurora Kinase B) • TFF1 (Trefoil Factor 1) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    1m
    Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures. (PubMed, Int J Ophthalmol)
    This study establishes and validates a seven-gene signature associated with metastasis and prognosis in UVM. The findings provide a framework for understanding molecular determinants of tumor progression and immune microenvironment alterations, and may offer guidance for future mechanistic studies and therapeutic exploration.
    Journal • Gene Signature
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    BAP1 (BRCA1 Associated Protein 1) • AURKA (Aurora kinase A) • KIF20A (Kinesin Family Member 20A) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    1m
    Dysregulation of atrazine-associated core gene networks and risk prediction in human cancers: Insights from integrated transcriptomics and network toxicology analyses. (PubMed, Ecotoxicol Environ Saf)
    This study demonstrates that atrazine promotes carcinogenesis by dysregulating conserved networks governing genomic stability, cell proliferation, metabolic adaptation, and immune microenvironment remodeling, providing a mechanistic framework linking aquatic atrazine exposure to multi-organ carcinogenesis and nominating HSD17B8-associated pathways for therapeutic intervention. These findings underscore the imperative for enhanced environmental monitoring of atrazine contamination.
    Journal
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    CDCA8 (Cell Division Cycle Associated 8) • FEN1 (Flap Structure-Specific Endonuclease 1) • MCM5 (Minichromosome Maintenance Complex Component 5) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    2ms
    RETRACTION: UBE2C Induces Cisplatin Resistance via ZEB1/2-Dependent Upregulation of ABCG2 and ERCC1 in NSCLC Cells. (PubMed, J Oncol)
    [This retracts the article DOI: 10.1155/2019/8607859.].
    Journal
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    ERCC1 (Excision repair cross-complementation group 1) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
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    cisplatin
    2ms
    Single-cell analysis identifies a stemness-associated tumor cell subpopulation and develops a prognostic scoring model in esophageal squamous cell carcinoma. (PubMed, Transl Oncol)
    Further analysis identified TFDP1 as a key gene associated with SASM and adverse prognosis, which was upregulated in tumor tissues and promoted ESCC cell proliferation in vitro. Overall, our study delineates stemness‑related tumor heterogeneity in ESCC, proposes a prognostic scoring system with immunological relevance, and highlights TFDP1 as a potential therapeutic target.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • MKI67 (Marker of proliferation Ki-67) • STMN1 (Stathmin 1) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)
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    TMB-L
    2ms
    MAZ-Mediated ubiquitin-conjugating enzyme E2C upregulation promotes breast cancer progression via the MAPK signaling pathway. (PubMed, Transl Oncol)
    Our findings highlight the critical role of the MAZ/UBE2C/MAPK signaling axis in the progression of breast cancer and identify potential novel therapeutic targets for its treatment.
    Journal
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    UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    2ms
    Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies. (PubMed, J Enzyme Inhib Med Chem)
    Enhanced sampling molecular dynamics simulations revealed that peptide folding landscapes are correlated with activity, with active peptides sampling transient β-sheet conformations compatible with binding. To the best of our knowledge, this is the first report of a peptide inhibitor of UBE2C enzymatic activity.
    Journal
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    UBE2C (Ubiquitin Conjugating Enzyme E2 C)
    2ms
    UBE2C/PTTG1 Regulates PANoptosis, Ferroptosis, and Autophagy to Improve Renal Ischemia-Reperfusion Injury. (PubMed, FASEB J)
    The effect of UBE2C may be reversed by intervention on PTTG1 expression, and UBE2C regulated PTTG1 expression by affecting its ubiquitination. Our results suggested that UBE2C might promote PTTG1 expression by enhancing its stability through decreasing ubiquitination to inhibit Panopolis and ferroptosis while facilitating autophagy to protect the kidney from IR-induced AKI.
    Journal
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    PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)