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    BIOMARKER:

    TYMS underexpression

    i
    Other names: TYMS, Thymidylate Synthetase, Thymidylate Synthase, TSase, HST422, TMS
    Entrez ID:
    7298
    Related biomarkers:
    Expression
    over2years
    Pemetrexed plus cisplatin in patients with previously treated advanced sarcoma: a multicenter, single-arm, phase II trial. (PubMed, ESMO Open)
    Combination therapy with pemetrexed and cisplatin was associated with clinically meaningful and sustained responses among patients with advanced and refractory STS. The combination therapy met its predefined primary study endpoint.
    Clinical • P2 data • Journal
    |
    ERCC1 (Excision repair cross-complementation group 1) • TYMS (Thymidylate Synthetase)
    |
    TYMS underexpression • TYMS expression
    |
    cisplatin • ifosfamide • pemetrexed