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    DRUG:

    TY-0584

    i
    Other names: TY-0584
    Company:
    TYK Medicines
    Drug class:
    TEAD inhibitor
    Related drugs:
    1year
    TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo (AACR 2023)
    Therefore, small molecules that target palmitoylation of TEAD have been explored and VT3989 (NCT04665206) and IK-930 (NCT05228015) have success to enter the clinical trials...In line with the results of the in-vitro experiments, another YAP/TEAD inhibitor TY-0536 in combination with TY-9591 significantly delay the tumor regrowth in the PC9 CDX mouse model...[Shengli Dong and Apeng Liang contributed equally to this work. Jun Li, Shengli Dong, and Apeng Liang are the corresponding authors.]
    Preclinical
    |
    NF2 (Neurofibromin 2)
    |
    NF2 deletion
    |
    IK-930 • TY-0584 • VT3989 • TY-9591