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DRUG:

TY-0540

i
Other names: TY-0540, TYK-00540, TY 0540, TYK 00540, TY0540, TYK00540
Associations
Trials
Company:
TYK Medicines
Drug class:
CDK4 inhibitor, CDK6 inhibitor, CDK2 inhibitor
Associations
Trials
9ms
New P1 trial
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TY-0540
over1year
TY-0540, a highly potent CDK2/4/6 inhibitor, attenuates acquired resistance against CDK4/6 inhibition (AACR 2023)
To test the effectiveness of the clinical candidate compound on CDK4/6i resistance models, two Palbociclib resistant cell populations (T47D-R, HCC1428-R) were in-house generated via gradient exposure of the cells to Palbociclib. #Meihua Li and Chengshan Niu contributed equally to this work. *Jun Li, Meihua Li and Chengshan Niu are the correspondent authors.
Preclinical
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCNE1 (Cyclin E1) • CDK7 (Cyclin Dependent Kinase 7) • CDK9 (Cyclin Dependent Kinase 9) • FOXM1 (Forkhead Box M1) • CDK1 (Cyclin-dependent kinase 1) • E2F1 (E2F transcription factor 1)
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HER-2 negative • CCNE1 amplification • MYC expression
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Ibrance (palbociclib) • TY-0540