Preclinical
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HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCNE1 (Cyclin E1) • CDK7 (Cyclin Dependent Kinase 7) • CDK9 (Cyclin Dependent Kinase 9) • FOXM1 (Forkhead Box M1) • CDK1 (Cyclin-dependent kinase 1) • E2F1 (E2F transcription factor 1)
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HER-2 negative • CCNE1 amplification • MYC expression
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Ibrance (palbociclib) • TY-0540