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GENE:

TXNIP (Thioredoxin Interacting Protein)

News alerts, weekly reports and conference planners

11d

CAR Signaling Informs Mechanisms to Enhance Metabolism and Function in γδ T Cells. (PubMed, Res Sq)

Finally, we designed a new synthetic co-stimulatory receptor that potentiates AP-1 activation resulting in improved in-vivo persistence. These results highlight fundamental biological differences between γδ and αβ T cells and support the development of cell type-specific receptor engineering strategies to maximize γδ CAR-T cell function and therapeutic benefit.

11 days ago

Journal • IO biomarker

TXNIP (Thioredoxin Interacting Protein) • PSCA (Prostate Stem Cell Antigen 2)

12d

Exploratory transcriptomics and in vivo analyses of suramin in tongue squamous cell carcinoma. (PubMed, Biomed Rep)

Effect size estimates were relatively large for both the group effect (partial η2=0.20) and the time x group interaction (partial η2=0.24), suggesting that the study may have been underpowered to detect this difference statistically. In conclusion, the present exploratory study suggests that suramin exerts a dual antitumor effect on tongue squamous cell carcinoma by suppressing proliferative transcriptional programs, and modulating extracellular and stress response pathways, providing a basis for future studies to further elucidate its therapeutic relevance.

12 days ago

Preclinical • Journal

AURKA (Aurora kinase A) • FOXM1 (Forkhead Box M1) • CDC20 (Cell Division Cycle 20) • MYBL2 (MYB Proto-Oncogene Like 2) • TNFSF10 (TNF Superfamily Member 10) • TXNIP (Thioredoxin Interacting Protein) • CCNB1 (Cyclin B1) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)

Germanin (suramin)

17d

LEAH: Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals (clinicaltrials.gov)

P=N/A, N=5909, Not yet recruiting, Gustave Roussy, Cancer Campus, Grand Paris | Initiation date: Jun 2025 --> Feb 2026

17 days ago

Trial initiation date

TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • STK11 (Serine/threonine kinase 11) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • POLE (DNA Polymerase Epsilon) • RUNX1 (RUNX Family Transcription Factor 1) • BAP1 (BRCA1 Associated Protein 1) • ETV6 (ETS Variant Transcription Factor 6) • MLH1 (MutL homolog 1) • CDK4 (Cyclin-dependent kinase 4) • MSH2 (MutS Homolog 2) • SMAD4 (SMAD family member 4) • CDH1 (Cadherin 1) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • POLD1 (DNA Polymerase Delta 1) • RAD51C (RAD51 paralog C) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • RAD51D (RAD51 paralog D) • DDX41 (DEAD-Box Helicase 41) • GATA2 (GATA Binding Protein 2) • DICER1 (Dicer 1 Ribonuclease III) • FLCN (Folliculin) • PRSS1 (Serine Protease 1) • SDHD (Succinate Dehydrogenase Complex Subunit D) • TXNIP (Thioredoxin Interacting Protein) • ANKRD26 (Ankyrin Repeat Domain Containing 26) • BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) • HOXB13 (Homeobox B13)

TP53 mutation • PTEN deletion

18d

Two pediatric supratentorial ependymal tumors with novel PLAG1 fusions. (PubMed, Acta Neuropathol Commun)

They also represent the first PLAG1 fusions identified in pediatric supratentorial ependymal tumors. These cases highlight the value of integrating histology, methylation profiling, and fusion detection, and suggest a new candidate supratentorial ependymal subtype with PLAG1 fusions, pending validation in larger series.

18 days ago

Journal

ATRX (ATRX Chromatin Remodeler) • CD34 (CD34 molecule) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • L1CAM (L1 cell adhesion molecule) • PLAG1 (PLAG1 Zinc Finger) • TXNIP (Thioredoxin Interacting Protein) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2) • PLAGL2 (PLAG1 Like Zinc Finger 2)

19d

Thioredoxin-interacting protein in radiation-induced pyroptosis and autophagy: Unveiling mechanisms and implications for preventing radiation-induced lung injury. (PubMed, Int J Biol Macromol)

Thus, TXNIP functions as a critical molecular switch balancing pyroptosis and autophagy. Our findings unveil a novel mechanistic link between these pathways and posit TXNIP as a promising therapeutic target for mitigating RILI.

19 days ago

Journal

NLRP3 (NLR Family Pyrin Domain Containing 3) • TXNIP (Thioredoxin Interacting Protein) • BECN1 (Beclin 1)

Thioredoxin-Binding protein 2 and apoptosis Signal-Regulating kinase 1: redox stress sensors and therapeutic targets in hepatocellular carcinoma. (PubMed, Med Oncol)

Translational challenges include context-dependent effects, biomarker limitations, and delivery specificity. Refining strategies to achieve precise, transient TBP2/ASK1 activation may unlock their tumor-suppressive potential while minimizing inflammatory risk, offering a novel avenue for HCC treatment.

1 month ago

Review • Journal

NLRP3 (NLR Family Pyrin Domain Containing 3) • TXNIP (Thioredoxin Interacting Protein) • MAPK8 (Mitogen-activated protein kinase 8) • MAP3K5 (Mitogen-Activated Protein Kinase Kinase Kinase 5)

Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival. (PubMed, Cell Death Dis)

We showed for the first time that TXNIP inhibition is also toxic against MM cells, interfering with UPR and autophagy. Thus, our data highlights the essential roles of CREB1 and TXNIP in MM cell survival under chronic stress, providing new insights into MM pathophysiology and novel therapeutic strategies for patients with high-risk disease.

1 month ago

Journal

NCAM1 (Neural cell adhesion molecule 1) • CREB1 (CAMP Responsive Element Binding Protein 1) • TXNIP (Thioredoxin Interacting Protein)

2ms

Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the RAPGEF3/4 signaling dependency in primary melanoma. (PubMed, bioRxiv)

Our data also show that EPACs promote melanoma growth by regulation of redox homeostasis and mitochondrial reactive oxygen species through activation of mechanistic target of rapamycin complex 1 (mTORC1) that stabilizes hypoxia-inducible factor 1-alpha (HIF-1α), a transcriptional activator of TXNIP and glycolytic enzymes. Our data suggest that targeting mechanisms that metastatic melanoma cells employ to bypass EPAC dependency as a potential therapeutic approach for melanoma.

2 months ago

Journal

BRAF (B-raf proto-oncogene) • PTEN (Phosphatase and tensin homolog) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • TXNIP (Thioredoxin Interacting Protein)

sirolimus

2ms

Oridonin Ameliorates Macrophage Oxidative Stress and Pyroptosis In Liver Ischemia-Reperfusion Injury by Inhibiting Mitochondrial ROS/TXNIP/NLRP3. (PubMed, Shock)

Oridonin effectively protects against LIRI by decreasing macrophage M1 polarization, oxidative stress, and pyroptosis through inhibition of the mitochondrial ROS/TXNIP/NLRP3 pathway.

2 months ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • TXNIP (Thioredoxin Interacting Protein) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule)

clodronate disodium

2ms

miR-135b-5p modulates the progression and clinical outcomes of oral squamous cell carcinoma through the negative regulation of TXNIP. (PubMed, Odontology)

Multivariate Cox regression analysis indicated that both were independent prognostic factors for OSCC. Conclusion The miR-135b-5p/TXNIP axis critically regulates OSCC progression through ferroptosis and may serve as a prognostic biomarker and therapeutic target for OSCC.

2 months ago

Clinical data • Journal

MIR135B (MicroRNA 135b) • TXNIP (Thioredoxin Interacting Protein)