TXNIP underexpression

Further studies found that the tumor suppressor effect of TXNIP was mediated by upregulating DNA damage-inducible transcript 4 (DDIT4) and inhibiting the phosphorylation of mechanistic target of rapamycin complex 1 (mTORC1) downstream substrate S6. Based on the above, our study explored the key role of TXNIP/DDIT4/mTORC1 suppression as a regulatory axis in the progression of OS, and laid the foundation for precise targeted therapy for OS.

Up-regulated miR-15b-5p further strengthened the pro-tumor effect of EXO, but this effect was reversed by overexpression of TXNIP. Overall, tumor-derived exosomal miR-15b-5p augments LCa through targeting down-regulation of TXNIP.