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    BIOMARKER:

    TXN2 rs4821494

    i
    Other names: TXN2, Thioredoxin 2, MT-TRX, Thioredoxin, Mitochondrial, MTRX, TRX2, Mitochondrial Thioredoxin, Thioredoxin-2, COXPD29, Mt-Trx, TXN
    Entrez ID:
    25828
    over2years
    Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a european cohort study. (PubMed, Free Radic Biol Med)
    Fourteen SNPs in twelve Se pathway genes (P ≤ 0.01) in interaction with Se status were also associated with BC risk. Higher Se status does not appear to be associated with BC risk, although activity of the selenoenzyme GPX3 may be inversely associated with premenopausal BC risk, and SNPs in the Se pathway alone or in combination with suboptimal Se status may influence BC risk.
    Journal
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    TXN2 (Thioredoxin 2)
    |
    TXN2 rs4821494
    over3years
    Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial. (PubMed, Clin Colorectal Cancer)
    TXN2 rs4821494 involved in the antioxidant system may predict the efficacy of cetuximab-based first-line chemotherapy in mCRC, warranting further validation studies.
    Journal
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    GPX4 (Glutathione Peroxidase 4)
    |
    GPX4 rs4807542 • TXN2 rs4821494
    |
    Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan • leucovorin calcium