^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TUSC7 overexpression

    i
    Other names: TUSC7, Tumor Suppressor Candidate 7, LINC00902, LSAMP Antisense RNA 3, Non-Protein Coding RNA 295, LSAMP Antisense RNA 3, NONHSAG035806.2, HSALNG0028235, NCRNA00295, LSAMP-AS1, LSAMP-AS3, LOC285194, LSAMPAS3
    Entrez ID:
    285194
    12ms
    lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration. (PubMed, Aging (Albany NY))
    TUSC7 suppresses human glioma cell proliferation and migration by negatively modulating miR-10a-5p and inhibiting the BDNF/ERK pathway, thus acting as a tumor suppressor gene in human gliomas.
    Journal
    |
    TUSC7 (Tumor Suppressor Candidate 7) • BDNF (Brain Derived Neurotrophic Factor)
    |
    TUSC7 overexpression • miR-10a-5p overexpression
    over2years
    The Biological Function of TUSC7/miR-1224-3p Axis in Triple-Negative Breast Cancer. (PubMed, Cancer Manag Res)
    TUSC7 overexpression significantly promoted the sensitivity of MDA-MB-468 cells to paclitaxel and carboplatin. The low TUSC7 expression is an independent prognostic factor of poor OS of TNBC patients. TUSC7 might inhibit breast cancer cell growth and metastasis both in vitro and vivo through binding with miR-1224-3P and regulating MAPK, PI3K/AKT, and NF-κB signaling pathways.
    Journal
    |
    TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TUSC7 (Tumor Suppressor Candidate 7)
    |
    TUSC7 overexpression
    |
    carboplatin • paclitaxel