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    BIOMARKER:

    TUBB1 rs151352

    i
    Other names: Tubulin Beta 1 Class VI, Tubulin Beta-1 Chain, Tubulin, Beta 1, Class VI Beta-Tubulin, TUBB1, DJ543J19.4
    Entrez ID:
    81027
    over2years
    Single-nucleotide polymorphism associations with efficacy and toxicity in metastatic castration-resistant prostate cancer treated with cabazitaxel. (PubMed, Pharmacogenomics)
    Genetic variants in mCRPC patients could explain different outcomes with cabazitaxel. Nonetheless, the small sample size and the high number of SNPs analyzed mean that the results are only hypothesis-generating and require further validation.
    Journal
    |
    ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) • TUBB1 (Tubulin Beta 1 Class VI)
    |
    CYP2C8 rs1058932 • CYP2C8 rs1341164 • TUBB1 rs151352
    |
    cabazitaxel