^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TUBA1C overexpression

    i
    Other names: TUBA1C, Tubulin Alpha 1c, Bcm948, TUBA6, Tubulin Alpha-1C Chain, Tubulin Alpha-6 Chain, Tubulin, Alpha 6, Alpha-Tubulin 6, MGC14580, MGC10851
    Entrez ID:
    84790
    over1year
    TUBA1C orchestrates the immunosuppressive tumor microenvironment and resistance to immune checkpoint blockade in clear cell renal cell carcinoma. (PubMed, Front Immunol)
    TUBA1C is a pivotal regulator in ccRCC, affecting both disease progression and the effectiveness of ICB therapy by fostering an immunosuppressive microenvironment mediated by the PI3K/AKT pathway. Additionally, TUBA1C holds promise, both as a prognostic biomarker and a therapeutic target, for enhancing responsiveness to ICB.
    Journal • Checkpoint inhibition • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker • Checkpoint block
    |
    TMB (Tumor Mutational Burden) • TUBA1C (Tubulin Alpha 1c)
    |
    TUBA1C overexpression
    2years
    Elevated expression of TUBA1C in breast cancer predicts poor prognosis. (PubMed, PLoS One)
    The GSEA identified that the high TUBA1C expression phenotype was differentially enriched in cell cycle, basal transcription factor, P53 signaling pathway, pathways in cancer, TOLL-like receptor signaling pathway, and NOD-like receptor signaling pathway. In summary, high messenger RNA (mRNA) expression of TUBA1C is an independent risk factor for poor prognosis of breast cancer.
    Journal • IO biomarker
    |
    TUBA1C (Tubulin Alpha 1c)
    |
    TUBA1C overexpression
    over2years
    TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle. (PubMed, BMC Cancer)
    The overexpression of TUBA1C in bladder cancer predicts a poor prognosis and may also be a potential immunotherapeutic target. As a prognostic marker, TUBA1C influences tumor progression by regulating the cell cycle.
    Journal • IO biomarker
    |
    TUBA1C overexpression