^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TTF1 negative

    i
    Other names: TTF1, Transcription Termination Factor 1, Transcription Termination Factor, RNA Polymerase I, TTF-1, TTF-I, RNA Polymerase I Termination Factor, Transcription Termination Factor I
    Entrez ID:
    7270
    Related biomarkers:
    Expression
    Others
    1year
    Fine-needle aspiration and effusion cytology of thoracic SMARCA4-deficient undifferentiated tumor and SMARCA4-deficient non-small cell lung carcinoma: A multi-institutional experience with 27 patients. (PubMed, Cancer Cytopathol)
    Although there is considerable clinical and cytopathologic overlap between SD-UT and SD-NSCLC, some key features allow for their distinction. SD-UT is mostly discohesive with rhabdoid or mixed rhabdoid-epithelioid features, whereas SD-NSCLC often has cohesive epithelioid morphology. The combination of clinical presentation, cytomorphology, and immunohistochemistry is essential for a definitive diagnosis.
    Journal • Cytology
    |
    SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63)
    |
    TTF1 negative
    1year
    Establishing a new human lung squamous cell carcinoma cell line, OMUL-1, expressing insulin-like growth factor 1 receptor and programmed cell death ligand 1. (PubMed, Thorac Cancer)
    We developed a novel new squamous cell lung carcinoma cell line, OMUL-1, that expresses IGF1R and PD-L1.
    Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • MET (MET proto-oncogene, receptor tyrosine kinase) • FGFR2 (Fibroblast growth factor receptor 2) • FGFR3 (Fibroblast growth factor receptor 3) • FGFR1 (Fibroblast growth factor receptor 1) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • FGFR4 (Fibroblast growth factor receptor 4) • IGF1R (Insulin-like growth factor 1 receptor) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FLT4 (Fms-related tyrosine kinase 4) • NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63)
    |
    PD-L1 expression • FGFR1 expression • IGF1R expression • FGFR2 expression • FGFR2b expression • FGFR3 expression • TTF1 negative
    |
    picropodophyllin (AXL1717)
    1year
    Intrapulmonary Biphasic Mesothelioma Misdiagnosed as Adenocarcinoma: Case Report and a Potential Diagnostic Pitfall. (PubMed, Onco Targets Ther)
    The patient was treated with a chemotherapy regimen of pemetrexed and carboplatin. Mesothelioma with predominantly intrapulmonary growth is extremely rare and poses a diagnostic pitfall. For this entity, subtle morphological features, selection of immunohistochemical markers, and electron microscopy are of great significance for definite diagnosis.
    Journal
    |
    WT1 (WT1 Transcription Factor) • CD34 (CD34 molecule) • NKX2-1 (NK2 Homeobox 1) • NAPSA (Napsin A Aspartic Peptidase)
    |
    TTF1 negative
    |
    carboplatin • pemetrexed
    1year
    Solitary subependymal giant cell astrocytoma lacking TSC1/2 mutations and TTF-1 expression: A potential diagnostic pitfall. (PubMed, Neuropathology)
    This case highlights the potential diagnostic pitfall of SEGA lacking TTF-1 expression and emphasizes the importance of considering this entity in the differential diagnosis of intraventricular tumors, even in the absence of TS and characteristic molecular alterations. The existence of TTF-1 negative SEGAs reveals that these tumors might also derive from TTF-1 negative cells in the subpendymal region.
    Journal
    |
    BAP1 (BRCA1 Associated Protein 1) • TSC2 (TSC complex subunit 2) • BCOR (BCL6 Corepressor) • TSC1 (TSC complex subunit 1) • TTF1 (Transcription Termination Factor 1) • NKX2-1 (NK2 Homeobox 1) • SOX2 • SYP (Synaptophysin) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
    |
    BAP1 mutation • TSC1 mutation • TSC2 mutation • NKX2-1 expression • TTF1 negative
    1year
    Clinicopathological characterization of tall cell carcinoma with reversed polarity of the breast: A case report and review of the litterature. (PubMed, Int J Surg Case Rep)
    TCCRP is a rare entity, which carries an excellent prognosis. A proper diagnosis is essential to conduct the best treatment next to a careful follow-up due to the ambiguous natural history of this rare entity.
    Review • Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • NKX2-1 (NK2 Homeobox 1)
    |
    TTF1 negative
    over1year
    SOUR AND SWEET: A CASE OF CONCURRENT NEOPLASMS, MALIGNANT AND BENIGN (CHEST 2024)
    At this time the patient was started on carboplatin, paclitaxel, and pembrolizumab. Despite incomplete staining results this case demonstrates possible concurrent PEComa and squamous cell lung cancer.
    Clinical • PD(L)-1 Biomarker
    |
    ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • MET (MET proto-oncogene, receptor tyrosine kinase) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • CEACAM5 (CEA Cell Adhesion Molecule 5) • NKX2-1 (NK2 Homeobox 1) • VIM (Vimentin) • CD68 (CD68 Molecule) • MLANA (Melan-A) • PAX8 (Paired box 8)
    |
    TP53 mutation • ALK rearrangement • TTF1 negative
    |
    Lung Cancer Mutation Panel
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel
    over1year
    A Curious Case of Clear Cell Morphology in a Patient with Lung Cancer: Diagnostic Challenges. (PubMed, Prague Med Rep)
    Next-generation sequencing for the salivary gland fusion panel, including EWSR1-ATF1 fusion and EWSR1 gene rearrangement for HCCC and MAML2 gene rearrangements for MEC, was negative. She was diagnosed with non-small cell lung cancer favouring squamous cell carcinoma with clear cell phenotype, a rare entity.
    Journal
    |
    EWSR1 (EWS RNA Binding Protein 1) • NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63) • ATF1 (Activating Transcription Factor 1) • NAPSA (Napsin A Aspartic Peptidase) • MAML2 (Mastermind Like Transcriptional Coactivator 2)
    |
    TTF1 negative
    over1year
    Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features. (PubMed, Virchows Arch)
    HNF4α-positive non-mucinous adenocarcinomas included TRU-type and non-TRU-type cases; the latter tended to exhibit the high-grade phenotype with frequent loss of SMARCA4, and A549 was a representative cell line.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • NKX2-1 (NK2 Homeobox 1) • HNF1A (HNF1 Homeobox A)
    |
    KRAS mutation • EGFR mutation • EGFR wild-type • KRAS wild-type • TTF1 negative
    over1year
    A Unique Case of Oncocytic Thyroid Cancer With an NBN Gene Pathogenic Variant (ENDO 2024)
    Due to disease progression, lenvatinib was initiated...Zoledronic acid was initiated for the treatment of the skeletal metastases, and palliative external beam radiation (2000 cGy in 5 fractions) was administered to the sternal lesion to alleviate the bone pain... The NBN gene encodes for the protein nibrin, a member of the MRE11/RAD50 complex that is involved in DNA repair. PVs in NBN are commonly identified in non-thyroidal malignancies such as breast and lung carcinomas. While NBN PVs are rarely reported in DTCs, as per our knowledge, this is the first described case of OTC with a PV in NBN as the molecular driver, manifesting with an aggressive disease course.
    Clinical
    |
    NRAS (Neuroblastoma RAS viral oncogene homolog) • RAD50 (RAD50 Double Strand Break Repair Protein) • NKX2-1 (NK2 Homeobox 1) • MRE11A (MRE11 homolog, double strand break repair nuclease) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • DAXX (Death-domain associated protein) • PAX8 (Paired box 8) • TG (Thyroglobulin)
    |
    TTF1 negative
    |
    Oncomine™ Comprehensive Assay v3M
    |
    Lenvima (lenvatinib) • zoledronic acid
    over1year
    Cytomorphology of monomorphic spindle epithelial tumor with thymus-like elements: A case with local recurrence after subtotal resection. (PubMed, Diagn Cytopathol)
    We herein present the cytologic findings of monomorphic SETTLE and highlight the potential cytomorphologic and immunophenotypic pitfalls. We also highlight how tumors with high-risk features can be a therapeutic challenge.
    Journal
    |
    NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63)
    |
    TTF1 negative
    almost2years
    Glioblastoma with Probable Intratumoral Adenocarcinoma Metastasis: A Rare Report with Review of Literature. (PubMed, Int J Surg Pathol)
    Glioblastomas may be susceptible to intratumoral metastasis due to the proliferating leaky vascular channels, however, the short survival of patients with glioblastoma may be responsible for the rarity of this occurrence. The documentation of these tumors is important as they may be important for clinical diagnosis and further treatment and prognosis.
    Review • Journal
    |
    EGFR (Epidermal growth factor receptor) • NKX2-1 (NK2 Homeobox 1)
    |
    EGFR amplification • IDH wild-type • TTF1 negative
    almost2years
    A Case of Resection of T2N0 Colon Cancer with Synchronous Solitary Lung Metastasis (PubMed, Gan To Kagaku Ryoho)
    The pulmonary mass was diagnosed as a metastatic adenocarcinoma based on immunostaining examination(CK7: negative, CK20: positive, TTF-1: negative, and CDX-2: positive). The patient is currently under follow-up as an outpatient without recurrence.
    Journal
    |
    NKX2-1 (NK2 Homeobox 1) • CDX2 (Caudal Type Homeobox 2)
    |
    TTF1 negative