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    GENE:

    TTC39B (Tetratricopeptide Repeat Domain 39B)

    i
    Other names: TTC39B, Tetratricopeptide Repeat Protein 39B, TPR Repeat Protein 39B, C9orf52, Chromosome 9 Open Reading Frame 52
    11ms
    MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy. (PubMed, Sci Rep)
    Furthermore, MT1H was undetectable in most gastric cell lines, but its expression was increased upon treatment with dexamethasone (Dexa) and the metal ion zinc. Therefore, MT1H emerges as a valuable tumor suppressor, a biomarker for the prognosis, and a promising therapeutic target in gastric cancer patients.
    Journal
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    SLC6A19 (Solute Carrier Family 6 Member 19) • TTC39B (Tetratricopeptide Repeat Domain 39B)
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    dexamethasone
    over4years
    TTC39B destabilizes retinoblastoma protein promoting hepatic lipogenesis in a sex-specific fashion. (PubMed, J Hepatol)
    We have uncovered a conserved sexual dimorphism in the regulation of hepatic lipogenic genes with effects of T39 mediated through pRb/E2F1 in females and VAPB/SCAP in both sexes. T39 inhibition could be a novel strategy to downregulate PNPLA3 and treat NAFLD in women.
    Journal
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    TTC39B (Tetratricopeptide Repeat Domain 39B) • E2F1 (E2F transcription factor 1)