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    BIOMARKER:

    TSG gene expression signature

    i
    Other names: TWSG1, Twisted Gastrulation BMP Signaling Modulator 1, TSG, Twisted Gastrulation Protein Homolog 1, Twisted Gastrulation Homolog 1 (Drosophila), Twisted Gastrulation Homolog 1
    almost3years
    Development and independent validation of a predictive gene expression signature based on RB1, PTEN, and TP53 in patients with metastatic hormone-sensitive metastatic prostate cancer (mHSPC). (ASCO 2023)
    218 pts were included: 125 treated with ADT + docetaxel (ADT+D) and 93 with ADT... Our results suggest that a TSGlow expression may predict the lack of benefit to taxanes in mHSPC pts, which may be useful to personalize the treatment. >
    Clinical • Metastases
    |
    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1)
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    PTEN mutation • PTEN-L • TSG gene expression signature
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    docetaxel
    3years
    Development and validation of a gene expression signature based on RB1, PTEN, and TP53 in patients with metastatic hormone-sensitive prostate cancer (mHSPC). (ASCO-GU 2023)
    Overall, 297 pts (baseline characteristics are shown) were included: 125 treated with ADT+Docetaxel (ADT+D) (54 and 71 in training and validation cohorts, respectively), 93 with ADT, and 79 with ADT+Abiraterone or Enzalutamide (ADT+A/E). A TSGgene expression signature is predictive of taxanes benefit in mHSPC pts and may be useful to personalize the treatment in this setting. >
    Clinical • Metastases
    |
    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • RB1 (RB Transcriptional Corepressor 1)
    |
    TP53 mutation • PTEN mutation • PTEN expression • TP53 expression • PTEN mutation + TP53 mutation • TSG gene expression signature
    |
    docetaxel • Xtandi (enzalutamide) • abiraterone acetate