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GENE:

TSC22D3 (TSC22 Domain Family Member 3)

News alerts, weekly reports and conference planners

27d

Novel Insights into TSC22D Family Genes in Metabolic Diseases and Cancer. (PubMed, Biomolecules)

In this review, we significantly synthesized advances in metabolism, showing that TSC22D3 could control lipid accumulation via modulating adipogenesis and adipose differentiation, while TSC22D4 could regulate insulin sensitivity and gluconeogenesis by affecting Akt (serine/threonine kinase, also known as protein kinase B, or PKB) phosphorylation. Moreover, we provide novel insights, including the fact that TSC22D family genes function as a double-edged sword in cancer due to the type of tumor and tumor microenvironment (TME).

27 days ago

Review • Journal

TGFB1 (Transforming Growth Factor Beta 1) • TSC22D3 (TSC22 Domain Family Member 3)

3ms

Transcriptome biomarkers of colon cancer liver metastasis response to neoadjuvant triplet chemotherapy: a case series. (PubMed, J Circ Biomark)

The triplet FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) may be considered an effective option in the neoadjuvant setting for metastatic colon cancer (mCRC). Data obtained indicate transcriptional discordance between the primary tumors and liver metastases during neoadjuvant FOLFOXIRI, with the pattern of DEGs involved in their response being distinct. The EPS8L2 transcript could be regarded as a candidate biomarker of liver complete response; however, prognostic conclusions cannot be drawn from this cohort.

3 months ago

Journal

IL7R (Interleukin 7 Receptor) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • SERPINE1 (Serpin Family E Member 1) • IL1RN (Interleukin 1 receptor antagonist) • NAMPT (Nicotinamide Phosphoribosyltransferase) • PER1 (Period Circadian Clock 1) • TAGLN (Transgelin) • ZBTB16 (Zinc Finger And BTB Domain Containing 16) • ATF3 (Activating Transcription Factor 3) • CTGF (Connective tissue growth factor) • DUSP1 (Dual Specificity Phosphatase 1) • GADD45B (Growth Arrest And DNA Damage Inducible Beta) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • TSC22D3 (TSC22 Domain Family Member 3)

5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium

5ms

Single-Cell RNA-Seq and Machine Learning Reveal Key Feature Genes of Astrocyte in Perioperative Neurocognitive Disorders. (PubMed, J Neurosci Res)

Transcription factor activity analysis highlighted distinct regulatory networks in astrocytes, providing insights into their functional differences in response to PND surgery. These findings offer a detailed aged hippocampal landscape of astrocyte dynamics and intercellular communication, contributing to our understanding of neuroinflammation and cognitive dysfunction following surgical stress.

5 months ago

Journal

TSC22D3 (TSC22 Domain Family Member 3)

5ms

Uncovering the Tumorigenic Blueprint of PFOS and PFOA Through Multi-Organ Transcriptomic Analysis of Biomarkers, Mechanisms, and Therapeutic Targets. (PubMed, Curr Issues Mol Biol)

All our findings provide hypotheses for PFOS/PFOA-induced tumorigenesis; however, experimental studies are required to establish translational relevance. All the R codes developed in this study are publicly available.

5 months ago

Journal

MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • SERPINE1 (Serpin Family E Member 1) • ALDOA (Aldolase Fructose-Bisphosphate A) • PLIN2 (Perilipin) • TRIB3 (Tribbles Pseudokinase 3) • ACOX1 (Acyl-CoA Oxidase 1) • PPARA (Peroxisome Proliferator Activated Receptor Alpha) • TSC22D3 (TSC22 Domain Family Member 3)

6ms

Molecular stratification of prostate cancer through sensory perception-related multi-omics analysis reveals chemoresistant mechanisms. (PubMed, Cell Oncol (Dordr))

This study establishes sensory perception-associated molecular subtypes in PCa and links CS1 chemoresistance to immune microenvironment reprogramming via TNF-CCL20 signaling. These findings offer mechanistic insights into PCa progression and suggest actionable targets to overcome therapeutic resistance.

6 months ago

Journal

CCL20 (C-C Motif Chemokine Ligand 20) • TSC22D3 (TSC22 Domain Family Member 3)

7ms

Deoxypodophyllotoxin induces apoptosis in non-small cell lung cancer cells by targeting the glucocorticoid receptor. (PubMed, Arch Biochem Biophys)

These findings suggest that DPT exerts its anticancer effects by disrupting the GR/TSC22D3 axis in NSCLC cells, highlighting its potential as a therapeutic agent for GR-associated cancers.

7 months ago

Journal • PARP Biomarker

CASP3 (Caspase 3) • NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) • ANXA5 (Annexin A5) • TSC22D3 (TSC22 Domain Family Member 3)

Mifeprex (mifepristone)

1year

Macrophage migration inhibitory factor in inflammasome formation and macrophage recruitment by cervical squamous cell carcinoma cells. (PubMed, Oncol Lett)

Therefore, it is suggested that MIF and TSC22D3 may induce macrophage infiltration in cervical cancer lesions and affect the tumor microenvironment by polarizing macrophages toward the M2 phenotype, thereby promoting CSCC progression. The present study highlights the potential of the MIF-TSC22D3 axis as a novel therapeutic target, which could conceivably help to improve the efficacy of immunotherapy in the treatment of recurrent or metastatic cervical cancer.

1 year ago

Journal

MIF (Macrophage Migration Inhibitory Factor) • TSC22D3 (TSC22 Domain Family Member 3)

1year

Cross-talk between cuproptosis and ferroptosis to identify immune landscape in cervical cancer for mRNA vaccines development. (PubMed, Eur J Med Res)

RT-qPCR validation confirmed the differential expression of these genes in clinical samples. Our findings identify TSC22D3, SQLE, ZNF419, and TFRC as candidate targets for mRNA vaccine development and offer a potential prognostic tool for personalized cervical cancer treatment.

1 year ago

Journal • IO biomarker

TSC22D3 (TSC22 Domain Family Member 3)

TSC2 mutation

1year

Identification of genetic and immune mechanisms linking preeclampsia and endometrial cancer: a prognostic model for survival and treatment response. (PubMed, Discov Oncol)

Additionally, the analysis showed that these genes are also implicated in the pathogenesis of PE, highlighting potential shared molecular mechanisms. Our findings suggest that these PE-related genes may serve as valuable prognostic biomarkers for EC and could lead to improved prognostic tools and personalized treatment strategies for EC patients.

1 year ago

Journal

PRSS23 (Serine Protease 23) • TSC22D3 (TSC22 Domain Family Member 3)

over1year

Identifying a CD8T cell signature in the tumor microenvironment to forecast gastric cancer outcomes from sequencing data. (PubMed, J Gastrointest Oncol)

A CD8T cell-related signature demonstrated robust prognostic predictive performance for GC. Our findings may reveal novel insights into the diagnosis and treatment of GC.

over 1 year ago

Journal

CXCR4 (Chemokine (C-X-C motif) receptor 4) • TNFA (Tumor Necrosis Factor-Alpha) • CLDN1 (Claudin 1) • ERRFI1 (ERBB Receptor Feedback Inhibitor 1) • TCEAL9 (Transcription Elongation Factor A Like 9) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • CD59 (CD59 Molecule) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) • RGS2 (Regulator Of G Protein Signaling 2) • SOCS3 (Suppressor Of Cytokine Signaling 3) • ZFP36 (ZFP36 Ring Finger Protein) • TSC22D3 (TSC22 Domain Family Member 3)

over1year

Ferroptosis-related genes DUOX1 and HSD17B11 are of considerable value in the diagnosis of LUAD patients. Their low expression suggests an increased recurrence rate and leads to a decrease in the patient quality of life.

over 1 year ago

Journal

AURKA (Aurora kinase A) • SLC7A5 (Solute Carrier Family 7 Member 5) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • ALOX15 (Arachidonate 15-Lipoxygenase) • IL33 (Interleukin 33) • SLC2A1 (Solute Carrier Family 2 Member 1) • ALOX15B (Arachidonate 15-Lipoxygenase Type B) • TSC22D3 (TSC22 Domain Family Member 3)