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    GENE:

    TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4)

    i
    Other names: TRPC4, Transient Receptor Potential Cation Channel Subfamily C Member 4, HTRP4, TRP4, Short Transient Receptor Potential Channel 4, Trp-Related Protein 4, Transient Receptor Potential Cation Channel, Subfamily C, Member 4, HTRP-4, HTrp-4, TrpC4, HTrp4
    Associations

    News

    Trials
    almost3years
    Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity. (PubMed, Biomolecules)
    Our study elucidated the possible role of TRP family genes in cancer progression and provided insights for further studies on TRP family genes as potential pan-cancer targets to develop diagnostic and therapeutic strategies.
    Journal • IO biomarker • Pan tumor
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    TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4)
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    PLX4720 • SB-590885
    3years
    Expression of pH-Sensitive TRPC4 in Common Skin Tumors. (PubMed, Int J Mol Sci)
    We found that all SCCs, NCNs, and MMs show positive TRPC4-expression, while BCCs do only in about half of the analyzed samples. These data render TRPC4 an immunohistochemical marker to distinguish SCC and BCC, and this also gives rise to future studies investigating the role of TRPC4 in tumor progression, and especially metastasis as BCCs very rarely spread and are mostly negative for TRPC4.
    Journal
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    TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4)