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    DRUG CLASS:

    TROP-2 inhibitor

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    News

    Trials
    6ms
    A Clinical Trial With KJ103 in Anti-GBM Disease (clinicaltrials.gov)
    P2, N=12, Active, not recruiting, Shanghai Bao Pharmaceuticals Co., Ltd. | Not yet recruiting --> Active, not recruiting
    Enrollment closed
    |
    cyclophosphamide
    6ms
    Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer (clinicaltrials.gov)
    P1/2, N=51, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Jul 2028 --> Jan 2028 | Trial primary completion date: Jul 2026 --> Oct 2027
    Trial completion date • Trial primary completion date • Platinum resistant
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    cyclophosphamide • fludarabine IV • TROP2-CAR-NK
    1year
    Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD) (clinicaltrials.gov)
    P1, N=42, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open • Combination therapy • Minimal residual disease
    |
    Erbitux (cetuximab) • cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    1year
    A Clinical Trial with KJ103 in Anti-GBM Disease (clinicaltrials.gov)
    P2, N=12, Not yet recruiting, Shanghai Bao Pharmaceuticals Co., Ltd.
    New P2 trial
    |
    cyclophosphamide
    over1year
    A Study to Evaluate the Safety and Tolerability of KJ103 in Healthy Adults (clinicaltrials.gov)
    P1, N=34, Completed, Shanghai Bao Pharmaceuticals Co., Ltd. | Active, not recruiting --> Completed | Trial completion date: Apr 2023 --> Aug 2023
    Trial completion • Trial completion date
    over1year
    Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD) (clinicaltrials.gov)
    P1, N=42, Not yet recruiting, M.D. Anderson Cancer Center | Trial primary completion date: Jan 2027 --> Jan 2029
    Trial primary completion date • Combination therapy • Minimal residual disease
    |
    Erbitux (cetuximab) • cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    over1year
    Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD) (clinicaltrials.gov)
    P1, N=42, Not yet recruiting, M.D. Anderson Cancer Center
    New P1 trial • Combination therapy • Minimal residual disease
    |
    Erbitux (cetuximab) • cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    2years
    Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA) (clinicaltrials.gov)
    P1, N=54, Recruiting, M.D. Anderson Cancer Center | Trial primary completion date: Apr 2028 --> Apr 2038
    Trial primary completion date • Metastases
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK (Neurotrophic receptor tyrosine kinase) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    PD-L1 expression • BRAF V600E • HR positive • HER-2 negative • BRAF V600 • TROP2 expression
    |
    cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    2years
    Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells Delivered Intraperitoneally for the Management of Platinum Resistant Ovarian Cancer, Mesonephric-like Adenocarcinoma, and Pancreatic Cancer (clinicaltrials.gov)
    P1/2, N=51, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open
    |
    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    BRCA2 mutation • BRCA1 mutation • TROP2 expression
    |
    cyclophosphamide • fludarabine IV • TROP2-CAR-NK
    2years
    Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA) (clinicaltrials.gov)
    P1, N=54, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting | Initiation date: Mar 2024 --> Oct 2023
    Enrollment open • Trial initiation date • Metastases
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK (Neurotrophic receptor tyrosine kinase) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    PD-L1 expression • BRAF V600E • HR positive • HER-2 negative • BRAF V600 • TROP2 expression
    |
    cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    2years
    Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA) (clinicaltrials.gov)
    P1, N=54, Not yet recruiting, M.D. Anderson Cancer Center
    New P1 trial • Metastases
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • NTRK (Neurotrophic receptor tyrosine kinase) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    PD-L1 expression • BRAF V600E • HR positive • HER-2 negative • BRAF V600 • TROP2 expression
    |
    cyclophosphamide • fludarabine IV • TROP2-CAR-NK • rimiducid (AP1903)
    over2years
    Study of MT-302 in Adults With Advanced or Metastatic Epithelial Tumors (clinicaltrials.gov)
    P1, N=48, Recruiting, Myeloid Therapeutics | Not yet recruiting --> Recruiting
    Enrollment open • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 negative
    |
    MT-302