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DRUG:

triptorelin

i
Other names: AY 25650, BIM 21003, BN 52014, CL 118532, Debio 8206, Debio 8206 CPP, Debio 8206 SC, WY 42422
Company:
Generic mfg.
Drug class:
GnRH agonist
9d
ROSE: Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment (clinicaltrials.gov)
P=N/A, N=450, Active, not recruiting, Ipsen | Recruiting --> Active, not recruiting | Trial completion date: Mar 2026 --> Jun 2026 | Trial primary completion date: Mar 2026 --> Jun 2026
Enrollment closed • Trial completion date • Trial primary completion date • HEOR
|
HER-2 (Human epidermal growth factor receptor 2) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • BRCA (Breast cancer early onset)
|
BRCA1 mutation • HR positive • HER-2 negative • HR positive + HER-2 negative • BRCA mutation
|
triptorelin
20d
New P2 trial • Metastases
|
docetaxel • Xtandi (enzalutamide) • Nubeqa (darolutamide) • Erleada (apalutamide) • triptorelin • Firmagon (degarelix) • Orgovyx (relugolix) • leuprolide acetate for depot suspension
26d
Trial primary completion date • Surgery
|
Prosigna™ Breast Cancer Prognostic Gene Signature Assay
|
Eligard (leuprolide acetate) • Nubeqa (darolutamide) • triptorelin • goserelin acetate • Viadur (leuprorelin implant)
26d
The Predictive Value of TMPRSS2-ERG Fusion in High Risk Prostate Cancer Patient (clinicaltrials.gov)
P=N/A, N=0, Withdrawn, Sir Mortimer B. Davis - Jewish General Hospital | N=65 --> 0 | Not yet recruiting --> Withdrawn
Enrollment change • Trial completion date • Trial withdrawal
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ERG (ETS Transcription Factor ERG) • TMPRSS2 (Transmembrane serine protease 2)
|
TMPRSS2-ERG fusion
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Eligard (leuprolide acetate) • triptorelin • goserelin acetate
1m
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET (clinicaltrials.gov)
P3, N=784, Recruiting, The University of Hong Kong | Trial completion date: Dec 2024 --> Mar 2025
Trial completion date
|
triptorelin
1m
The Efficacy and Safety of Prostatectomy for Castration-Naive Oligometastatic Prostate Cancer (clinicaltrials.gov)
P2, N=130, Completed, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Active, not recruiting --> Completed | Trial completion date: May 2025 --> Dec 2024
Trial completion • Trial completion date • Metastases
|
abiraterone acetate • prednisone • triptorelin • goserelin acetate
1m
Management of Castration-Resistant Prostate Cancer with Oligometastases (clinicaltrials.gov)
P2/3, N=102, Active, not recruiting, Sir Mortimer B. Davis - Jewish General Hospital | Recruiting --> Active, not recruiting | Trial primary completion date: Apr 2025 --> Apr 2027
Enrollment closed • Trial primary completion date
|
Xtandi (enzalutamide) • Eligard (leuprolide acetate) • triptorelin • goserelin acetate
1m
LIBELULA: A Study to Assess the Efficacy, Safety and Pharmacokinetics of Debio 4326 in Pediatric Participants Receiving Gonadotropin-Releasing Hormone Agonist Therapy for Central Precocious Puberty (clinicaltrials.gov)
P3, N=53, Recruiting, Debiopharm International SA | Trial completion date: Dec 2027 --> Mar 2028 | Trial primary completion date: Jul 2026 --> Dec 2026
Trial completion date • Trial primary completion date
|
triptorelin
1m
Micro RNAs to Predict Response to Androgen Deprivation Therapy (clinicaltrials.gov)
P=N/A, N=42, Completed, Medical College of Wisconsin | Active, not recruiting --> Completed
Trial completion
|
docetaxel • Xtandi (enzalutamide) • abiraterone acetate • bicalutamide • Erleada (apalutamide) • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
2ms
Potential Effects of Soy Isoflavones and Broccoli Extract on Oxidative Stress, Autophagy, and Apoptosis Gene Markers in Endometriosis. (PubMed, Int J Fertil Steril)
The findings of the current study demonstrated that the simultaneous consumption of a certain amount of broccoli extract and SI can be considered as a promising therapeutic strategy for treatment of endometriosis.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • BECN1 (Beclin 1)
|
BCL2 expression • BAX expression
|
triptorelin
2ms
Triptorelin for Early Diagnosis of Hypogonadotrophic Hypogonadism (clinicaltrials.gov)
P=N/A, N=48, Enrolling by invitation, Hospital de Niños R. Gutierrez de Buenos Aires
New trial
|
triptorelin
2ms
Study on Human Bioequivalence of Triprerelin Acetate for Injection (clinicaltrials.gov)
P1, N=120, Recruiting, The Affiliated Hospital of Qingdao University
New P1 trial
|
triptorelin
2ms
EORTC-1206: Androgen Deprivation Therapy in Advanced Salivary Gland Cancer (clinicaltrials.gov)
P2, N=149, Completed, European Organisation for Research and Treatment of Cancer - EORTC | Active, not recruiting --> Completed | Trial completion date: Jul 2024 --> Feb 2024
Trial completion • Trial completion date • Metastases
|
AR expression
|
cisplatin • carboplatin • paclitaxel • doxorubicin hydrochloride • bicalutamide • triptorelin
2ms
Genetic Predisposition to Cancer Associated with a Germline Pathogenic BRCA2 Variant: A Clinical Case Report (SABCS 2024)
Subsequently, he received androgen deprivation therapy (ADT) for 6 months with triptorelin and bicalutamide...The pathological stage was pT1c pN1mi.The Oncotype DX study had a Recurrence Score (RS) of 22 points, leading to a recommendation for adjuvant chemotherapy with Docetaxel-Cyclophosphamide for 4 cycles, followed by tamoxifen...Early detection through screening and appropriate medical follow-up improves the prognosis in patients carrying PV in BRCA2. Therefore, risk control monitoring and adequate genetic counseling are necessary.
Clinical • BRCA Biomarker • Case report
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
|
HER-2 negative • ER expression • ER overexpression • HER-2 negative + AR positive + ER positive • HER-2 negative + ER positive • HER-2 negative + PGR positive
|
Oncotype DX Breast Recurrence Score®Test
|
docetaxel • tamoxifen • cyclophosphamide • bicalutamide • triptorelin
2ms
Trial completion • Enrollment change
|
triptorelin
3ms
ROSE: Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment (clinicaltrials.gov)
P=N/A, N=419, Recruiting, Ipsen | Trial completion date: Dec 2025 --> Mar 2026 | Trial primary completion date: Dec 2025 --> Mar 2026
Trial completion date • Trial primary completion date • HEOR
|
HER-2 (Human epidermal growth factor receptor 2) • BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • BRCA (Breast cancer early onset)
|
BRCA1 mutation • HR positive • HER-2 negative • HR positive + HER-2 negative • BRCA mutation • PTEN mutation + HR positive
|
triptorelin
4ms
BOUQUET: A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors (clinicaltrials.gov)
P2, N=176, Active, not recruiting, Hoffmann-La Roche | Trial completion date: Dec 2028 --> May 2028 | Trial primary completion date: May 2028 --> Feb 2028
Trial completion date • Trial primary completion date
|
ER (Estrogen receptor)
|
Avastin (bevacizumab) • Lynparza (olaparib) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • paclitaxel • Kadcyla (ado-trastuzumab emtansine) • Cotellic (cobimetinib) • Verzenio (abemaciclib) • cyclophosphamide • letrozole • ipatasertib (RG7440) • triptorelin • goserelin acetate • Itovebi (inavolisib) • giredestrant (GDC-9545)
4ms
Phase classification
|
bicalutamide • triptorelin
4ms
Trial completion date
|
triptorelin
4ms
New trial
|
triptorelin
4ms
Trial completion • Metastases
|
triptorelin
5ms
REAL6T: A Study to Observe Demography and the Outcome of Prostate Cancer Patients Treated With 6-month Triptorelin Formulation in Italy (clinicaltrials.gov)
P=N/A, N=300, Recruiting, Ipsen | Trial completion date: Jun 2024 --> Sep 2024 | Trial primary completion date: Jun 2024 --> Sep 2024
Trial completion date • Trial primary completion date
|
triptorelin
5ms
Trial completion • Metastases
|
triptorelin
5ms
New P2 trial • Combination therapy
|
PD-L1 (Programmed death ligand 1)
|
Keytruda (pembrolizumab) • bicalutamide • triptorelin • goserelin acetate • Firmagon (degarelix) • Orgovyx (relugolix) • leuprolide acetate for depot suspension
6ms
Potential therapeutic properties of broccoli extract and soy isoflavones on improvement endometriosis and involved oxidative parameters. (PubMed, Horm Mol Biol Clin Investig)
BE in combination with SI decreased the growth and histopathologic grades of transplanted endometrial implants. These herbal compounds may have the potential therapeutic effect to be used as an alternative medication for the treatment of endometriosis.
Journal
|
TNFA (Tumor Necrosis Factor-Alpha)
|
triptorelin
6ms
First Strike, Second Strike Therapies for High Risk Metastatic Castration Sensitive Prostate Cancer (clinicaltrials.gov)
P2, N=32, Active, not recruiting, H. Lee Moffitt Cancer Center and Research Institute | Recruiting --> Active, not recruiting | Trial completion date: Jan 2027 --> Jul 2028 | Trial primary completion date: Jan 2027 --> Jul 2027
Enrollment closed • Trial completion date • Trial primary completion date • Metastases
|
docetaxel • Tevimbra (tislelizumab-jsgr) • Xtandi (enzalutamide) • abiraterone acetate • triptorelin • Firmagon (degarelix) • Orgovyx (relugolix) • leuprolide acetate for depot suspension
6ms
New P3 trial
|
triptorelin
6ms
CDK4/6 and aromatase inhibitors as first-line treatment in metastatic high-grade neuroendocrine carcinoma of the breast: A case report. (PubMed, Clin Case Rep)
Herein, we present the first case ever reported, concerning a female patient with de novo metastatic breast NEC who received hormonal therapy, a combination of a CDK4/6 inhibitor palbociclib with letrozole and triptorelin, as first-line treatment with significant clinical and radiological response. As most NECs are estrogen receptor and/or progesterone receptor positive and HER-2 negative, we suggest that hormonal therapy may play a leading role even in the first-line setting. The present report provides a new treatment strategy by incorporating CDK4/6 inhibitors in the therapeutic armamentarium of breast NECs.
Journal • Metastases
|
HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
|
Ibrance (palbociclib) • letrozole • triptorelin
6ms
PRIMORDIUM: A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Hormone-Sensitive Prostate Cancer (clinicaltrials.gov)
P3, N=694, Active, not recruiting, Janssen Pharmaceutica N.V., Belgium | Recruiting --> Active, not recruiting | N=412 --> 694
Enrollment closed • Enrollment change
|
Erleada (apalutamide) • triptorelin • goserelin acetate
6ms
Trial completion
|
triptorelin
6ms
Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP (clinicaltrials.gov)
P4, N=134, Not yet recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
New P4 trial
|
triptorelin
7ms
Enrollment open • Metastases
|
Xtandi (enzalutamide) • abiraterone acetate • Nubeqa (darolutamide) • Erleada (apalutamide) • triptorelin • goserelin acetate • Firmagon (degarelix) • Orgovyx (relugolix) • leuprolide acetate for depot suspension
7ms
PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study (clinicaltrials.gov)
P4, N=60, Not yet recruiting, University Hospital, Ghent | Initiation date: Apr 2024 --> Jul 2024
Trial initiation date
|
triptorelin
8ms
Enrollment change
|
ER (Estrogen receptor)
|
Avastin (bevacizumab) • Lynparza (olaparib) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • paclitaxel • Kadcyla (ado-trastuzumab emtansine) • Cotellic (cobimetinib) • Verzenio (abemaciclib) • cyclophosphamide • letrozole • ipatasertib (RG7440) • triptorelin • goserelin acetate • Itovebi (inavolisib) • giredestrant (GDC-9545)
8ms
Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate Cancer (clinicaltrials.gov)
P2, N=19, Active, not recruiting, University of Colorado, Denver | Trial completion date: Apr 2024 --> Apr 2025
Trial completion date
|
Xtandi (enzalutamide) • triptorelin • goserelin acetate • Firmagon (degarelix) • leuprolide acetate for depot suspension
9ms
Real World Evidence Study on Metastatic Prostate Cancer in the Pirkanmaa Hospital District in Finland (clinicaltrials.gov)
P=N/A, N=1, Completed, Pfizer | Trial completion date: Jun 2023 --> Apr 2024 | Trial primary completion date: Jun 2023 --> Apr 2024
Trial completion date • Trial primary completion date • HEOR • Real-world evidence • Real-world • Metastases
|
docetaxel • Xtandi (enzalutamide) • abiraterone acetate • cabazitaxel • Erleada (apalutamide) • triptorelin • goserelin acetate • Firmagon (degarelix) • Xofigo (radium Ra-223 dichloride) • leuprolide acetate for depot suspension
9ms
New P2 trial • Metastases
|
Xtandi (enzalutamide) • abiraterone acetate • Nubeqa (darolutamide) • Erleada (apalutamide) • triptorelin • goserelin acetate • Firmagon (degarelix) • Orgovyx (relugolix) • leuprolide acetate for depot suspension
9ms
Enrollment closed
|
ER (Estrogen receptor)
|
Avastin (bevacizumab) • Lynparza (olaparib) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • paclitaxel • Kadcyla (ado-trastuzumab emtansine) • Cotellic (cobimetinib) • Verzenio (abemaciclib) • cyclophosphamide • letrozole • ipatasertib (RG7440) • triptorelin • goserelin acetate • Itovebi (inavolisib) • giredestrant (GDC-9545)
9ms
Micro RNAs to Predict Response to Androgen Deprivation Therapy (clinicaltrials.gov)
P=N/A, N=42, Active, not recruiting, Medical College of Wisconsin | N=60 --> 42
Enrollment change
|
docetaxel • Xtandi (enzalutamide) • abiraterone acetate • bicalutamide • Erleada (apalutamide) • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
9ms
EORTC-1532: ODM-201 vs Androgen Deprivation Therapy in Hormone naïve Prostate Cancer (clinicaltrials.gov)
P2, N=61, Active, not recruiting, European Organisation for Research and Treatment of Cancer - EORTC | Trial completion date: May 2024 --> Dec 2036
Trial completion date
|
Nubeqa (darolutamide) • triptorelin • goserelin acetate • Firmagon (degarelix)