Triple Negative Breast Cancer

In contrast, TROP2-directed ADCs demonstrate negligible cardiac signals. Given the elevated fatality rate of serious cardiac events associated with T-DXd observed in real-world data, we propose a risk-stratified cardiac monitoring algorithm incorporating high-sensitivity troponin and global longitudinal strain for patients receiving next-generation ADCs.

Present findings are from a small sample cohort and need further validation from a larger cohort. The online version contains supplementary material available at 10.1007/s13193-025-02427-0.

It also discusses recent advances in targeting strategies. The review provides insights for developing effective anti-cancer therapies.

These underscore the relevance of age-related biological factors in shaping breast cancer characteristics. However, among Indonesian women over 45 years old, the proportion of high breast density remains remarkably high (65.6%), suggesting that factors beyond age-such as genetic, hormonal, or lifestyle influences-may contribute to the persistence of dense breast tissue in this population.

BA-AgNPs show an average hydrodynamic size of 169 nm, enhanced antioxidant activity, and selective cytotoxicity toward breast cancer cells with IC50 values of 90 µg/mL (MCF-7) and 25.9 µg/mL (MDA-MB-231), while showing low toxicity toward healthy cells. The study findings revealed increased ROS generation, mitochondrial membrane depolarization, lysosomal disruption, induction of apoptosis, cell cycle arrest, inhibition of migration, and disruption of redox homeostasis upon BA-AgNPs treatment, highlighting their potential as a promising nanoformulation for future breast cancer therapeutics.

In conclusion, immune infiltration phenotype is a crucial prognostic biomarker for TNBC patients. LTB contributes to enhanced immune infiltration, making as a promising target for immune therapy in TNBC.

Circulating tumor DNA-based minimal residual disease assays offer a promising tool for refining risk stratification and potentially guiding the extent of surgery and adjuvant therapy. These strategies represent a transformative movement toward biologically tailored, response-adapted, less invasive treatments for early breast cancer to optimize quality of life without compromising long-term outcomes.

P3, N=1000, Not yet recruiting, Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Overall, SSP exerts therapeutic effects by mitigating colony formation, invasion, migration, metastasis, osteoclast differentiation, and osteolytic destruction. This may provide new drugs for the prevention and treatment of BCBM.

Thus, VALD-3 treatment initiated the ROS/JNK/Bax-mitochondrial apoptosis pathway, leading to caspase-3 activation and GSDME cleavage, thereby executing pyroptosis. These findings suggest that GSDME-dependent pyroptosis is a novel mechanism by which VALD-3 eradicates cancer cells and offer new insights into potential clinical applications for anticancer therapies.

We discuss key lncRNAs implicated in TNBC pathogenesis and their potential as diagnostic biomarkers, prognostic indicators and therapeutic targets. By elucidating the complex interplay between lncRNAs and oncogenic pathways, this review underscores the promise of lncRNA-based strategies in improving TNBC management and patient outcomes.