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    GENE:

    TRIM7 (Tripartite Motif Containing 7)

    i
    Other names: TRIM7, Tripartite Motif Containing 7, RNF90, GNIP, Glycogenin-Interacting Protein, E3 Ubiquitin-Protein Ligase TRIM7, Tripartite Motif Protein TRIM7, RING Finger Protein 90, Tripartite Motif-Containing Protein 7, Tripartite Motif-Containing 7
    Associations

    News

    Trials
    26d
    Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation. (PubMed, Int J Biol Sci)
    A nephroprotective agent gastrodin was found to decrease NLRP6 and relieve mitochondria-mediated apoptosis caused by high fructose, possibly through promoting TRIM7-driven Bok mRNA degradation and FAM213A antioxidant effect. This study uncovered that high NLRP6 expression-driven mitochondria-mediated apoptosis could participate in podocyte injury and the suppression of NLRP6 by gastrodin may be an attractive therapeutic approach for podocyte injury.
    Journal
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    BCL2 (B-cell CLL/lymphoma 2) • NLRP6 (NLR Family Pyrin Domain Containing 6) • TRIM7 (Tripartite Motif Containing 7)
    7ms
    The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review. (PubMed, Cancers (Basel))
    This review identifies TRIM proteins that are involved in urological cancers. Some of these proteins have the potential to be the therapeutic target.
    Review • Journal
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    TRIM33 (Tripartite Motif Containing 33) • TRIM24 (Tripartite Motif Containing 24) • TRIM21 (Tripartite Motif Containing 21) • TRIM28 (Tripartite Motif Containing 28) • TRIM37 (Tripartite Motif Containing 37) • TRIM38 (Tripartite Motif Containing 38) • TRIM46 (Tripartite Motif Containing 46) • TRIM47 (Tripartite Motif Containing 47) • TRIM58 (Tripartite Motif Containing 58) • TRIM7 (Tripartite Motif Containing 7) • TRIM29 (Tripartite Motif Containing 29) • TRIM9 (Tripartite Motif Containing 9)
    9ms
    A brief overview of the E3 ubiquitin ligase: TRIM7. (PubMed, Cell Signal)
    In addition, it might serve as a reliable biomarker for monitoring the progression of idiopathic pulmonary fibrosis and also inhibits the progression of atherosclerosis. In summary, TRIM7 plays critical roles in different pathophysiological processes, and it might be a predictive and therapeutic target in certain human diseases.
    Journal
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    TRIM7 (Tripartite Motif Containing 7)
    11ms
    Doxorubicin-induced apoptosis is exacerbated by MG53 and associated with altered Akt signaling in H9c2 cells. (PubMed, Mol Pharmacol)
    SIGNIFICANCE STATEMENT: This study reveals that mitsugumin 53 exacerbates doxorubicin-induced apoptosis in H9c2 cells, associated with altered protein kinase B signaling. Targeting mitsugumin 53 may offer a novel therapeutic approach to mitigate doxorubicin-associated cardiotoxicity.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • TRIM7 (Tripartite Motif Containing 7)
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    doxorubicin hydrochloride
    11ms
    Human tripartite motif-containing protein 71 NCL-1/HT2A/LIN-41 domain crystal structure and its potential natural inhibitors. (PubMed, Int J Biol Macromol)
    Molecular dynamics simulations confirmed protein-ligand complexes stability. In summary, human TRIM71 NHL domain crystal structure provides a foundation for understanding its structural features while exploring two potential inhibitors for therapeutic applications.
    Journal
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    CDKN1A (Cyclin-dependent kinase inhibitor 1A) • TRIM7 (Tripartite Motif Containing 7)
    1year
    E3 ubiquitin ligase TRIM7 alleviates LPS-induced acute lung injury via inhibiting NLRP3 inflammasome activation. (PubMed, Am J Pathol)
    The regulatory effect of TRIM7 on ALI depends on NLRP3 inflammasome. This investigation for the first time found the inhibitory effect of TRIM7 on ALI and the activation of NLRP3 inflammasome, which providing new targets and ideas for the mechanism research and treatment of ALI.
    Journal
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    NLRP3 (NLR Family Pyrin Domain Containing 3) • TRIM7 (Tripartite Motif Containing 7)
    over1year
    Tripartite Motif Containing 71 Suppresses Tumor Growth by Down-Regulating eIF5A2 Expression in Laryngeal Squamous Cell Carcinoma. (PubMed, Appl Biochem Biotechnol)
    In contrast, overexpression of eIF5A2 abolished the anti-tumor effects of TRIM71. In summary, TRIM71 may exert its anti-tumor effects through regulating eIF5A2, highlighting the potential of TRIM71 as an effective therapeutic target for the treatment of LSCC.
    Journal
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    EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) • TRIM7 (Tripartite Motif Containing 7)
    over1year
    Replenishing co-downregulated miR-100-5p and miR-125b-5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption. (PubMed, Mol Oncol)
    Cells were treated with demethylating 5-azacytidine and pyrosequencing was performed...In summary, combination miR-100-5p/miR-125b-5p mimic replenishment or TRIM71kd caused growth inhibition in malignant GCT cells via cell cycle disruption. Further studies are now warranted, including mimic treatment alongside conventional platinum-based chemotherapy.
    Journal
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    MIR100 (MicroRNA 100) • MIR99A (MicroRNA 99a) • MIRLET7B (MicroRNA Let-7b) • TRIM7 (Tripartite Motif Containing 7)
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    azacitidine
    over1year
    Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway. (PubMed, Phytomedicine)
    The study determines the anti-liver cancer effect of FAN and first describes the positive regulatory effect of TRIM7 on Nrf2 signaling. We reveal that TRIM7/Nrf2 signaling served as a target of FAN-induced ROS accumulation in HCC, which helps to clarify the mechanism of action of FAN against HCC and provides a theoretical basis for FAN as an anti-cancer drug.
    Journal
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    KEAP1 (Kelch Like ECH Associated Protein 1) • TRIM7 (Tripartite Motif Containing 7)
    over1year
    TRIM72 inhibits cell migration and epithelial-mesenchymal transition by attenuating FAK/akt signaling in colorectal cancer. (PubMed, Heliyon)
    TRIM72 interacted with Focal Adhesion Kinase (FAK), implicating the FAK/Akt signaling axis in colon cancer spread. Lower TRIM72 levels were associated with reduced survival rates, highlighting its potential as a prognostic marker and therapeutic target in CRC.
    Journal
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    TRIM7 (Tripartite Motif Containing 7)
    over1year
    Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues. (PubMed, Front Immunol)
    Anti-eIF3 autoantibodies, recently identified in polymyositis (PM) patients, are rarely detected (<1%) and associated with a favorable prognosis. Elucidating these autoantibodies is anticipated to not only assist in early diagnosis and disease stratification but also inform targeted therapeutic interventions, emphasizing the intricate interplay between autoimmunity, cellular dysfunction, and clinical outcomes in IIMs.
    Review • Journal
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    CD8 (cluster of differentiation 8) • IFIH1 (Interferon Induced With Helicase C Domain 1) • TRIM7 (Tripartite Motif Containing 7)
    over1year
    Oncofetal TRIM71 drives liver cancer carcinogenesis through remodeling CEBPA-mediated serine/glycine metabolism. (PubMed, Theranostics)
    Furthermore, we identified that all-trans-retinoic acid (ATRA) combined with e1A binding protein p300 (EP300) inhibitor A-485 repressed TRIM71, attenuated glycine/serine metabolism, and inhibited liver cancer cell proliferation with high TRIM71 levels. We demonstrated the oncofetal status in liver cancer and highlighted the crucial role of TRIM71 and provided potential therapeutic strategies and liver cancer-specific biomarker for liver cancer patients.
    Journal
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    CEBPA (CCAAT Enhancer Binding Protein Alpha) • EP300 (E1A binding protein p300) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • TRIM7 (Tripartite Motif Containing 7)