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    GENE:

    TRIM6 (Tripartite Motif Containing 6)

    i
    Other names: TRIM6, Tripartite Motif Containing 6, RNF89, RING-Type E3 Ubiquitin Transferase TRIM6, Tripartite Motif-Containing Protein 6, RING Finger Protein 89, Tripartite Motif-Containing 6
    Associations

    News

    Trials
    5ms
    TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration. (PubMed, PLoS One)
    TRIM6 is expressed at low levels in AML, correlates with immune infiltration, and may affect AML progression through the PI3K/AKT signaling pathway.
    Journal
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    TP53 (Tumor protein P53) • NPM1 (Nucleophosmin 1) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TRIM6 (Tripartite Motif Containing 6)
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    TP53 mutation • NPM1 mutation • RUNX1 mutation • ASXL1 mutation
    6ms
    TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity. (PubMed, J Exp Clin Cancer Res)
    Our results elucidate TRIM6-mediated suppression of antitumor immunity as a novel mechanism underlying ICB resistance in MSS gastric cancer, positioning TRIM6 as both a predictive biomarker and therapeutic target for immunologically cold subtypes.
    Journal • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker
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    MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • STING (stimulator of interferon response cGAMP interactor 1) • TRIM6 (Tripartite Motif Containing 6)
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    MSI-H/dMMR
    8ms
    SRSF3 is oncogenic in breast but tumor-suppressive in liver by differential regulation of gene expression. (PubMed, bioRxiv)
    Moreover, Srsf3 KO suppresses the expression of ERα and Foxa genes to reduce Lifr and Egfr but induce Myc expression and promote liver cancer in female mice. Together, our data highlight a new functional paradigm of SRSF3 at its physiological level in tissue context-dependent gene regulation.
    Journal
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    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • LIFR (LIF Receptor Subunit Alpha) • E2F1 (E2F transcription factor 1) • SOX4 (SRY-Box Transcription Factor 4) • SRSF3 (Serine And Arginine Rich Splicing Factor 3) • TRIM6 (Tripartite Motif Containing 6) • TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4)
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    HER-2 expression • EGFR expression
    10ms
    STAT3-mediated upregulation of TRIM6 promotes hepatocellular carcinoma invasion through the DDX58-Snail1 axis. (PubMed, Sci Rep)
    The degradation of DDX58 by TRIM6 alleviates its inhibitory effects on Snail1, thereby facilitating EMT and enhancing the invasive potential of HCC cells. These findings establish the STAT3-TRIM6-DDX58-Snail1 axis as a pivotal pathway in HCC progression, offering novel insights into the molecular underpinnings of HCC metastasis and highlighting TRIM6 as a potential therapeutic target and prognostic biomarker in HCC.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • SNAI1 (Snail Family Transcriptional Repressor 1) • DDX58 (DExD/H-Box Helicase 58) • TRIM6 (Tripartite Motif Containing 6)
    10ms
    TRIM6 Promotes Cell Cycle and Growth by Modulating p53 Signaling Pathway in Lung Adenocarcinoma. (PubMed, Int J Gen Med)
    Mechanistically, TRIM6 enhanced the biological capacity of LUAD cells through the p53 signaling pathway. Our study identifies TRIM6 is a potential oncogene and a prognostic target through the regulation of p53 signaling pathway in LUAD.
    Journal
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    TRIM6 (Tripartite Motif Containing 6)
    11ms
    Construction and Validation of T-cell Exhaustion-related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma. (PubMed, Curr Pharm Biotechnol)
    The TEX score has prognosis-predicting value for DLBCL and might be a valuable biomarker to guide clinical decision-making for patients with DLBCL.
    Journal • Gene Signature • IO biomarker
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    BIRC3 (Baculoviral IAP repeat containing 3) • BAG4 (BAG Cochaperone 4) • TRIM6 (Tripartite Motif Containing 6)
    12ms
    Construction and Validation of A Prognostic Model for Lung Adenocarcinoma Based on Ferroptosis-related Genes (PubMed, Zhongguo Fei Ai Za Zhi)
    This study successfully established a LUAD risk scoring model composed of 12 ferroptosis-related genes. In the future, this model is expected to be used in conjunction with the tumor-node-metastasis (TNM) staging system for prognostic predictions in LUAD patients.
    Journal
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    LDHA (Lactate dehydrogenase A) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • KRT6A (Keratin 6A) • MIR31HG (MIR31 Host Gene) • TRIM6 (Tripartite Motif Containing 6) • OGFRP1 (Opioid Growth Factor Receptor Pseudogene 1)
    almost2years
    TRIM6 promotes glioma malignant progression by enhancing FOXO3A ubiquitination and degradation. (PubMed, Transl Oncol)
    These observations imply that the TRIM6-FOXO3A axis could potentially serve as an innovative focus for intervening in glioma.
    Journal
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    FOXO3 (Forkhead box O3) • TRIM6 (Tripartite Motif Containing 6)
    almost2years
    Prognostic Cell Death Index for Lung Adenocarcinoma: A Comprehensive Transcriptome-Based Analysis of Twelve Programmed Cell Death Pattern Genes. (PubMed, Front Biosci (Landmark Ed))
    The CDI, based on PCD genes, serves as a robust prognostic tool for LUAD, offering profound insights into tumor biology, immune response, and personalized treatment strategies. This study underscores the pivotal role of PCD mechanisms in LUAD pathogenesis and identifies potential therapeutic targets.
    Journal
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    CD4 (CD4 Molecule) • CD68 (CD68 Molecule) • ERO1A (Endoplasmic Reticulum Oxidoreductase 1 Alpha) • TRIM6 (Tripartite Motif Containing 6) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    almost2years
    TRIM6 Promotes ROS-Mediated Inflammasome Activation and Pyroptosis in Renal Tubular Epithelial Cells via Ubiquitination and Degradation of GPX3 Protein. (PubMed, Front Biosci (Landmark Ed))
    TRIM6 increases oxidative stress and promotes the pyroptosis of HK2 cells by regulating GPX3 ubiquitination. These findings could contribute to the development of novel drugs for the treatment of RF.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • GPX3 (Glutathione Peroxidase 3) • TRIM6 (Tripartite Motif Containing 6) • CASP1 (Caspase 1)
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    IL6 expression
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    BMS-986299
    over2years
    TRIM6: An Upregulated Biomarker with Prognostic Significance and Immune Correlations in Gliomas. (PubMed, Biomolecules)
    TRIM6 plays a crucial role in promoting cell viability, clonogenic potential, migration, and invasion in glioma cells. It may regulate glioma progression by modulating cytokine-cytokine receptor interaction, leading to an inflammatory response and an imbalance in immunomodulation, thereby representing a potential therapeutic target.
    Journal
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    TRIM6 (Tripartite Motif Containing 6)
    over2years
    Silencing TRIM6 inhibits the growth and angiogenesis of gliomas by regulating VEGFA. (PubMed, J Chem Neuroanat)
    TRIM6 promoted glioma cell proliferation, migration and angiogenesis through the FOXM1-VEGFA pathway. Therefore, TRIM6 has the potential to be explored as a novel therapeutic target in clinical.
    Journal
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    FOXM1 (Forkhead Box M1) • TRIM6 (Tripartite Motif Containing 6)
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    VEGFA overexpression • VEGFA expression • FOXM1 overexpression